TY - JOUR
T1 - Pressure modulates monocyte migration
AU - Singhal, P. C.
AU - Sagar, P.
AU - Gupta, S.
AU - Arya, M.
AU - Gupta, M.
AU - Prasad, A.
AU - Loona, R.
AU - Sharma, P.
AU - Mattana, J.
N1 - Funding Information:
This work was supported from a grant #2RO1 DA 06753 from the National Institutes of Health, Bethesda, MD.
PY - 1997/11
Y1 - 1997/11
N2 - Migration of monocytes into the subendothelial space of the aorta has been considered to be an important event in the development of atherosclerosis. Because hypertension is commonly associated with atherosclerosis, we studied the effect of applied pressure on the migration of monocytes. Direct applied pressure increased the migration (P < .001) of monocytes across a filter when compared with normal atmospheric pressure. The migration of monocytes was found to be directly related to the amount of the applied pressure. Amlodipine, a calcium channel blocker, attenuated the migration of monocytes under normal as well as increased pressure conditions in a dose-dependent manner. These studies provide a basis to speculate on the role of direct pressure in the migration of monocytes into the subendothelial space and the possibility that vasoactive agents may modulate the migration of monocytes independent of their pressure-lowering effect.
AB - Migration of monocytes into the subendothelial space of the aorta has been considered to be an important event in the development of atherosclerosis. Because hypertension is commonly associated with atherosclerosis, we studied the effect of applied pressure on the migration of monocytes. Direct applied pressure increased the migration (P < .001) of monocytes across a filter when compared with normal atmospheric pressure. The migration of monocytes was found to be directly related to the amount of the applied pressure. Amlodipine, a calcium channel blocker, attenuated the migration of monocytes under normal as well as increased pressure conditions in a dose-dependent manner. These studies provide a basis to speculate on the role of direct pressure in the migration of monocytes into the subendothelial space and the possibility that vasoactive agents may modulate the migration of monocytes independent of their pressure-lowering effect.
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U2 - 10.1016/S0895-7061(97)00271-9
DO - 10.1016/S0895-7061(97)00271-9
M3 - Article
C2 - 9397250
AN - SCOPUS:0031278628
SN - 0895-7061
VL - 10
SP - 1297
EP - 1301
JO - American Journal of Hypertension
JF - American Journal of Hypertension
IS - 11
ER -