Preserved executive function in high-performing elderly is driven by large-scale recruitment of prefrontal cortical mechanisms

Pierfilippo De Sanctis, Manuel Gomez-Ramirez, Pejman Sehatpour, Glenn R. Wylie, John J. Foxe

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

High-density electrical mapping of event-related potentials was used to investigate the neural processes that permit some elderly subjects to preserve high levels of executive functioning. Two possibilities pertain: (1) high-performance in elderly subjects is underpinned by similar processing mechanisms to those seen in young adults; that is, these individuals display minimal functional decay across the lifespan, or (2) preserved function relies on successfully recruiting and amplifying control processes to compensate for normal sensory-perceptual decline with age. Fifteen young and nineteen elderly participants, the latter split into groups of high and low performers, regularly alternated between a letter and a number categorization task, switching between tasks every third trial (AAA-BBB-AAA : : : ). This allowed for interrogation of performance during switch, repeat, and preparatory pre-switch trials. Robust effects of age were observed in both frontal and parietal components of the task-switching network. Greatest differences originated over prefrontal regions, with elderly subjects generating amplified, earlier, and more differentiated patterns of activity. This prefrontal amplification was evident only in high-performing (HP) elderly, and was strongest on pre-switch trials when participants prepared for an upcoming task-switch. Analysis of the early transient and late sustained activity using topographic analyses and source localization collectively supported a unique and elaborated pattern of activity across frontal and parietal scalp in HP-elderly, wholly different to that seen in both young and low-performing elderly. On this basis, we propose that preserved executive function in HP-elderly is driven by large-scale recruitment and enhancement of prefrontal cortical mechanisms.

Original languageEnglish (US)
Pages (from-to)4198-4214
Number of pages17
JournalHuman Brain Mapping
Volume30
Issue number12
DOIs
StatePublished - Dec 2009
Externally publishedYes

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Executive Function
Scalp
Evoked Potentials
Young Adult

Keywords

  • Aging
  • ERP
  • Event-related potentials
  • Executive control
  • Frontal cortex
  • High-density electrical mapping
  • Task-switching

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Preserved executive function in high-performing elderly is driven by large-scale recruitment of prefrontal cortical mechanisms. / De Sanctis, Pierfilippo; Gomez-Ramirez, Manuel; Sehatpour, Pejman; Wylie, Glenn R.; Foxe, John J.

In: Human Brain Mapping, Vol. 30, No. 12, 12.2009, p. 4198-4214.

Research output: Contribution to journalArticle

De Sanctis, Pierfilippo ; Gomez-Ramirez, Manuel ; Sehatpour, Pejman ; Wylie, Glenn R. ; Foxe, John J. / Preserved executive function in high-performing elderly is driven by large-scale recruitment of prefrontal cortical mechanisms. In: Human Brain Mapping. 2009 ; Vol. 30, No. 12. pp. 4198-4214.
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