Presentation and management of a patient with subcutaneous metastatic transitional cell carcinoma of the bladder

Hannah H. Alphs, Jennifer Miles-Thomas, Frank Attenello, Janis M. Taube, Gustavo Fonseca, Thomas J. Guzzo, Mark P. Schoenberg, Trinity J. Bivalacqua

Research output: Contribution to journalArticle

Abstract

Background: A 60-year-old female with a 6-month history of muscle-invasive transitional cell carcinoma of the bladder presented with an enlarging subcutaneous lesion involving her right flank. She had previously undergone radical cystectomy, bilateral pelvic lymphadenectomy and ileal orthotopic neobladder reconstruction. Investigations: Axial fused fluorodeoxyglucose PET-CT of the chest, abdomen and pelvis, fine needle aspiration with direct ultrasound guidance, excisional biopsy and immunohistochemistry. Diagnosis: Subcutaneous and liver metastases of transitional cell carcinoma. Management: Wide local excision of the subcutaneous lesion followed by combination gemcitabine-cisplatin chemotherapy. Gemcitabine was administered at a dose of 1,000 mg/m2 on days 1, 8, and 15, and cisplatin was administered at a dose of 75 mg/m2 on day 1; the schedule was repeated every 28 days for three cycles.

Original languageEnglish (US)
Pages (from-to)691-694
Number of pages4
JournalNature Clinical Practice Urology
Volume5
Issue number12
DOIs
StatePublished - 2008
Externally publishedYes

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gemcitabine
Transitional Cell Carcinoma
Cisplatin
Urinary Bladder
Cystectomy
Fine Needle Biopsy
Lymph Node Excision
Pelvis
Abdomen
Appointments and Schedules
Thorax
Immunohistochemistry
Neoplasm Metastasis
Biopsy
Drug Therapy
Muscles
Liver

ASJC Scopus subject areas

  • Urology

Cite this

Alphs, H. H., Miles-Thomas, J., Attenello, F., Taube, J. M., Fonseca, G., Guzzo, T. J., ... Bivalacqua, T. J. (2008). Presentation and management of a patient with subcutaneous metastatic transitional cell carcinoma of the bladder. Nature Clinical Practice Urology, 5(12), 691-694. https://doi.org/10.1038/ncpuro1253

Presentation and management of a patient with subcutaneous metastatic transitional cell carcinoma of the bladder. / Alphs, Hannah H.; Miles-Thomas, Jennifer; Attenello, Frank; Taube, Janis M.; Fonseca, Gustavo; Guzzo, Thomas J.; Schoenberg, Mark P.; Bivalacqua, Trinity J.

In: Nature Clinical Practice Urology, Vol. 5, No. 12, 2008, p. 691-694.

Research output: Contribution to journalArticle

Alphs, HH, Miles-Thomas, J, Attenello, F, Taube, JM, Fonseca, G, Guzzo, TJ, Schoenberg, MP & Bivalacqua, TJ 2008, 'Presentation and management of a patient with subcutaneous metastatic transitional cell carcinoma of the bladder', Nature Clinical Practice Urology, vol. 5, no. 12, pp. 691-694. https://doi.org/10.1038/ncpuro1253
Alphs, Hannah H. ; Miles-Thomas, Jennifer ; Attenello, Frank ; Taube, Janis M. ; Fonseca, Gustavo ; Guzzo, Thomas J. ; Schoenberg, Mark P. ; Bivalacqua, Trinity J. / Presentation and management of a patient with subcutaneous metastatic transitional cell carcinoma of the bladder. In: Nature Clinical Practice Urology. 2008 ; Vol. 5, No. 12. pp. 691-694.
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