Preparation of 198Au(I)-labelled gold-chloroquine complex [198Au(PPh3)(CQ)]PF6 as a potential antimalarial agent

E. Dadachova

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

198Au(I)-labelled gold-chloroquine complex [198Au(PPh3)(CQ)]PF6 has been prepared for the enhancement of antimalarial action against chloroquine-resistant strains of Plasmodium falciparum of recently reported [Au(PPh3)(CQ)]PF6. [198Au(PPh3)(CQ)]PF6 was synthesized via 3-step route starting with irradiated in the reactor for 2 hours Au foil and purified on Sep-Pak® C18 cartridge. Specific activity of the complex was 1.5 mCi/mg. The possibility of using metal complexes radiolabelled with therapeutic radioisotopes for treatment of chloroquine-resistant malaria is discussed.

Original languageEnglish (US)
Pages (from-to)287-292
Number of pages6
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume42
Issue number3
DOIs
StatePublished - 1999
Externally publishedYes

Fingerprint

Chloroquine
Antimalarials
Gold
Coordination Complexes
Plasmodium falciparum
Radioisotopes
Metal foil
Malaria
Therapeutics

Keywords

  • Au
  • [Au(PPh)(CQ)]PF x 2HO
  • Chloroquine-resistance
  • Malaria
  • Radioisotopes
  • Radiotherapy

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Medicine
  • Analytical Chemistry
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

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abstract = "198Au(I)-labelled gold-chloroquine complex [198Au(PPh3)(CQ)]PF6 has been prepared for the enhancement of antimalarial action against chloroquine-resistant strains of Plasmodium falciparum of recently reported [Au(PPh3)(CQ)]PF6. [198Au(PPh3)(CQ)]PF6 was synthesized via 3-step route starting with irradiated in the reactor for 2 hours Au foil and purified on Sep-Pak{\circledR} C18 cartridge. Specific activity of the complex was 1.5 mCi/mg. The possibility of using metal complexes radiolabelled with therapeutic radioisotopes for treatment of chloroquine-resistant malaria is discussed.",
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author = "E. Dadachova",
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AU - Dadachova, E.

PY - 1999

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N2 - 198Au(I)-labelled gold-chloroquine complex [198Au(PPh3)(CQ)]PF6 has been prepared for the enhancement of antimalarial action against chloroquine-resistant strains of Plasmodium falciparum of recently reported [Au(PPh3)(CQ)]PF6. [198Au(PPh3)(CQ)]PF6 was synthesized via 3-step route starting with irradiated in the reactor for 2 hours Au foil and purified on Sep-Pak® C18 cartridge. Specific activity of the complex was 1.5 mCi/mg. The possibility of using metal complexes radiolabelled with therapeutic radioisotopes for treatment of chloroquine-resistant malaria is discussed.

AB - 198Au(I)-labelled gold-chloroquine complex [198Au(PPh3)(CQ)]PF6 has been prepared for the enhancement of antimalarial action against chloroquine-resistant strains of Plasmodium falciparum of recently reported [Au(PPh3)(CQ)]PF6. [198Au(PPh3)(CQ)]PF6 was synthesized via 3-step route starting with irradiated in the reactor for 2 hours Au foil and purified on Sep-Pak® C18 cartridge. Specific activity of the complex was 1.5 mCi/mg. The possibility of using metal complexes radiolabelled with therapeutic radioisotopes for treatment of chloroquine-resistant malaria is discussed.

KW - Au

KW - [Au(PPh)(CQ)]PF x 2HO

KW - Chloroquine-resistance

KW - Malaria

KW - Radioisotopes

KW - Radiotherapy

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