Abstract
198Au(I)-labelled gold-chloroquine complex [198Au(PPh3)(CQ)]PF6 has been prepared for the enhancement of antimalarial action against chloroquine-resistant strains of Plasmodium falciparum of recently reported [Au(PPh3)(CQ)]PF6. [198Au(PPh3)(CQ)]PF6 was synthesized via 3-step route starting with irradiated in the reactor for 2 hours Au foil and purified on Sep-Pak® C18 cartridge. Specific activity of the complex was 1.5 mCi/mg. The possibility of using metal complexes radiolabelled with therapeutic radioisotopes for treatment of chloroquine-resistant malaria is discussed.
Original language | English (US) |
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Pages (from-to) | 287-292 |
Number of pages | 6 |
Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
Volume | 42 |
Issue number | 3 |
DOIs | |
State | Published - 1999 |
Externally published | Yes |
Keywords
- Au
- Chloroquine-resistance
- Malaria
- Radioisotopes
- Radiotherapy
- [Au(PPh)(CQ)]PF x 2HO
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry
- Radiology Nuclear Medicine and imaging
- Drug Discovery
- Spectroscopy
- Organic Chemistry