Preparation of indapamide slow-release pellets

Wei Jia, Mingfeng Qiu, Xia Sun, Yungping Qiu, Mingming Su

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

During the process of developing a slow-release formulation of indapamide, researchers created a drug-containing pellet coated with Eudragit® RS100 (Rohm GMbH & Co. KG, Darmstadt, Germany) to control the rate at which the drug was released. The two main variables were the agglomerants used in the pellet preparation and the amount of Eudragit RS100 used to coat them. The optimal outcome was indicated by the greatest number of drug-containing pellets recovered through an 18- to 24-mesh sieve and a satisfactory 24-hour release curve. The kinetics of dissolution fit the Higuchi kinetics model. Stability tests of the drug pellets showed no notable changes in the rate of drug release, related substances (mean byproducts or impurities from interactions or decompositions), and drug content.

Original languageEnglish (US)
Pages (from-to)238-246
Number of pages9
JournalAdvances in Therapy
Volume21
Issue number4
DOIs
StatePublished - Jan 1 2004
Externally publishedYes

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Keywords

  • Coating
  • Eudragit RS100
  • Indapamide
  • Slow-release formulations

ASJC Scopus subject areas

  • Pharmacology (medical)

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