Preoperative statin therapy is not associated with biochemical recurrence after radical prostatectomy

Our experience and meta-analysis

Alon Y. Mass, Ilir Agalliu, Juliana Laze, Herbert Lepor

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Purpose: The effect of statins on prostate cancer recurrence has been investigated in several studies with inconsistent results. We investigated whether statins were associated with biochemical recurrence in a large cohort of men after radical prostatectomy. We also performed a meta-analysis of existing studies. Materials and Methods: A total of 1,446 patients who underwent radical prostatectomy at New York University were followed a median of 57 months for biochemical recurrence events. Baseline demographic and clinical characteristics were compared between 437 statin users and 1,009 nonusers. Kaplan-Meier curves and Cox models were used to examine biochemical recurrence-free survival by statin use. A meta-analysis was performed with data from our cohort and 5 published studies using the random effects model. Results: Statin users were slightly older and more likely to have diabetes (p <0.01). They were similar to nonusers in race and body mass index. Although preoperative prostate specific antigen and tumor stage were similar between the 2 groups, the proportion of patients with pathological Gleason score 7-10 tumors was slightly higher among statin users (p = 0.03). The biochemical recurrence-free survival rate was 87.4% and 89.0% for statin users and nonusers, respectively, at the end of followup (log rank p = 0.26). Overall biochemical recurrence was not associated with statin use (HR 1.15, 95% CI 0.82-1.61). Results were similar when patients were stratified by D'Amico low and intermediate or high risk groups. Meta-analysis revealed no overall association between statins and biochemical recurrence (pooled HR 1.00, 95% CI 0.80-1.19). Conclusions: Our findings are consistent with the results of the meta-analysis, which indicated that preoperative statin use does not impact the overall risk of biochemical recurrence.

Original languageEnglish (US)
Pages (from-to)786-791
Number of pages6
JournalJournal of Urology
Volume188
Issue number3
DOIs
StatePublished - Sep 2012

Fingerprint

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Prostatectomy
Meta-Analysis
Recurrence
Therapeutics
Neoplasm Grading
Prostate-Specific Antigen
Proportional Hazards Models
Neoplasms
Prostatic Neoplasms
Body Mass Index
Survival Rate
Demography

Keywords

  • hydroxymethylglutaryl-CoA reductase inhibitors
  • neoplasm recurrence local
  • prostate
  • prostatic neoplasms
  • risk

ASJC Scopus subject areas

  • Urology

Cite this

Preoperative statin therapy is not associated with biochemical recurrence after radical prostatectomy : Our experience and meta-analysis. / Mass, Alon Y.; Agalliu, Ilir; Laze, Juliana; Lepor, Herbert.

In: Journal of Urology, Vol. 188, No. 3, 09.2012, p. 786-791.

Research output: Contribution to journalArticle

@article{05dfc1103fc64e8a8be5a08a9478c127,
title = "Preoperative statin therapy is not associated with biochemical recurrence after radical prostatectomy: Our experience and meta-analysis",
abstract = "Purpose: The effect of statins on prostate cancer recurrence has been investigated in several studies with inconsistent results. We investigated whether statins were associated with biochemical recurrence in a large cohort of men after radical prostatectomy. We also performed a meta-analysis of existing studies. Materials and Methods: A total of 1,446 patients who underwent radical prostatectomy at New York University were followed a median of 57 months for biochemical recurrence events. Baseline demographic and clinical characteristics were compared between 437 statin users and 1,009 nonusers. Kaplan-Meier curves and Cox models were used to examine biochemical recurrence-free survival by statin use. A meta-analysis was performed with data from our cohort and 5 published studies using the random effects model. Results: Statin users were slightly older and more likely to have diabetes (p <0.01). They were similar to nonusers in race and body mass index. Although preoperative prostate specific antigen and tumor stage were similar between the 2 groups, the proportion of patients with pathological Gleason score 7-10 tumors was slightly higher among statin users (p = 0.03). The biochemical recurrence-free survival rate was 87.4{\%} and 89.0{\%} for statin users and nonusers, respectively, at the end of followup (log rank p = 0.26). Overall biochemical recurrence was not associated with statin use (HR 1.15, 95{\%} CI 0.82-1.61). Results were similar when patients were stratified by D'Amico low and intermediate or high risk groups. Meta-analysis revealed no overall association between statins and biochemical recurrence (pooled HR 1.00, 95{\%} CI 0.80-1.19). Conclusions: Our findings are consistent with the results of the meta-analysis, which indicated that preoperative statin use does not impact the overall risk of biochemical recurrence.",
keywords = "hydroxymethylglutaryl-CoA reductase inhibitors, neoplasm recurrence local, prostate, prostatic neoplasms, risk",
author = "Mass, {Alon Y.} and Ilir Agalliu and Juliana Laze and Herbert Lepor",
year = "2012",
month = "9",
doi = "10.1016/j.juro.2012.05.011",
language = "English (US)",
volume = "188",
pages = "786--791",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Preoperative statin therapy is not associated with biochemical recurrence after radical prostatectomy

T2 - Our experience and meta-analysis

AU - Mass, Alon Y.

AU - Agalliu, Ilir

AU - Laze, Juliana

AU - Lepor, Herbert

PY - 2012/9

Y1 - 2012/9

N2 - Purpose: The effect of statins on prostate cancer recurrence has been investigated in several studies with inconsistent results. We investigated whether statins were associated with biochemical recurrence in a large cohort of men after radical prostatectomy. We also performed a meta-analysis of existing studies. Materials and Methods: A total of 1,446 patients who underwent radical prostatectomy at New York University were followed a median of 57 months for biochemical recurrence events. Baseline demographic and clinical characteristics were compared between 437 statin users and 1,009 nonusers. Kaplan-Meier curves and Cox models were used to examine biochemical recurrence-free survival by statin use. A meta-analysis was performed with data from our cohort and 5 published studies using the random effects model. Results: Statin users were slightly older and more likely to have diabetes (p <0.01). They were similar to nonusers in race and body mass index. Although preoperative prostate specific antigen and tumor stage were similar between the 2 groups, the proportion of patients with pathological Gleason score 7-10 tumors was slightly higher among statin users (p = 0.03). The biochemical recurrence-free survival rate was 87.4% and 89.0% for statin users and nonusers, respectively, at the end of followup (log rank p = 0.26). Overall biochemical recurrence was not associated with statin use (HR 1.15, 95% CI 0.82-1.61). Results were similar when patients were stratified by D'Amico low and intermediate or high risk groups. Meta-analysis revealed no overall association between statins and biochemical recurrence (pooled HR 1.00, 95% CI 0.80-1.19). Conclusions: Our findings are consistent with the results of the meta-analysis, which indicated that preoperative statin use does not impact the overall risk of biochemical recurrence.

AB - Purpose: The effect of statins on prostate cancer recurrence has been investigated in several studies with inconsistent results. We investigated whether statins were associated with biochemical recurrence in a large cohort of men after radical prostatectomy. We also performed a meta-analysis of existing studies. Materials and Methods: A total of 1,446 patients who underwent radical prostatectomy at New York University were followed a median of 57 months for biochemical recurrence events. Baseline demographic and clinical characteristics were compared between 437 statin users and 1,009 nonusers. Kaplan-Meier curves and Cox models were used to examine biochemical recurrence-free survival by statin use. A meta-analysis was performed with data from our cohort and 5 published studies using the random effects model. Results: Statin users were slightly older and more likely to have diabetes (p <0.01). They were similar to nonusers in race and body mass index. Although preoperative prostate specific antigen and tumor stage were similar between the 2 groups, the proportion of patients with pathological Gleason score 7-10 tumors was slightly higher among statin users (p = 0.03). The biochemical recurrence-free survival rate was 87.4% and 89.0% for statin users and nonusers, respectively, at the end of followup (log rank p = 0.26). Overall biochemical recurrence was not associated with statin use (HR 1.15, 95% CI 0.82-1.61). Results were similar when patients were stratified by D'Amico low and intermediate or high risk groups. Meta-analysis revealed no overall association between statins and biochemical recurrence (pooled HR 1.00, 95% CI 0.80-1.19). Conclusions: Our findings are consistent with the results of the meta-analysis, which indicated that preoperative statin use does not impact the overall risk of biochemical recurrence.

KW - hydroxymethylglutaryl-CoA reductase inhibitors

KW - neoplasm recurrence local

KW - prostate

KW - prostatic neoplasms

KW - risk

UR - http://www.scopus.com/inward/record.url?scp=84864917742&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864917742&partnerID=8YFLogxK

U2 - 10.1016/j.juro.2012.05.011

DO - 10.1016/j.juro.2012.05.011

M3 - Article

VL - 188

SP - 786

EP - 791

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 3

ER -