Prenatally Diagnosed Aggressive Intracranial Immature Teratoma–Clinicopathological Correlation

Hiroki Nariai, Dana E. Price, Ajit Jada, Lauren Weintraub, Karen M. Weidenheim, William A. Gomes, Adam S. Levy, Ira Richmond Abbott, III, Fatema Malbari

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Objective: To describe clinicopathological correlation of congenital intracranial immature teratoma. Methods: A retrospective case analysis from a tertiary medical center. Results: We report a case of an intracranial immature teratoma detected prenatally at 35 weeks of gestation. The tumor showed rapid growth, causing acute hydrocephalus requiring subsequent ventriculoperitoneal shunting. Resective surgery was performed within 2 weeks after birth. The infant died at day of life 29. Histological examination revealed an immature teratoma, with high MIB1/Ki-67 proliferation index. Conclusion/Implications: Intracranial immature teratoma with high MIB1/Ki-67 proliferation index may serve as an independent poor prognostic factor.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalFetal and Pediatric Pathology
StateAccepted/In press - May 3 2016


  • congenital brain tumor
  • Immature teratoma
  • MIB1/Ki-67 proliferation index
  • prenatal diagnosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Pediatrics, Perinatology, and Child Health


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