Prenatal morphine exposure enhances seizure susceptibility but suppresses long-term potentiation in the limbic system of adult male rats

Libor Velíšek, Patric K. Stanton, Solomon L. Moshe, Ilona Vathy

Research output: Contribution to journalArticle

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Abstract

The present study examined the effects of prenatal morphine exposure on NMDA-dependent seizure susceptibility in the entorhinal cortex (EC), and on activity-dependent synaptic plasticity at Schaffer collateral and perforant path synapses in the hippocampus. During perfusion with Mg2+-free ACSF, an enhancement of epileptiform discharges was found in the EC of slices from prenatally morphine-exposed male rats. A submaximal tetanic stimulation (2x50 Hz/1 s) in control slices elicited LTP at the Schaffer collateral-CA1 synapses, but neither LTP nor LTD was evoked at the perforant path-DG synapses. In slices from prenatally morphine-exposed adult male rats, long-term potentiation of synaptic transmission was not observed at Schaffer collateral-CA1 synapses, while the submaximal tetanus now elicited frank LTD of synaptic EPSPs at perforant path synapses. These data suggest that prenatal morphine exposure enhances the susceptibility of entorhinal cortex to the induction of epileptiform activity, but shifts long-term plasticity of hippocampal synapses in favor of LTD. Theme: Neural basis of behaviour. Topic: Drugs of abuse: opioids and others. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)186-193
Number of pages8
JournalBrain Research
Volume869
Issue number1-2
DOIs
StatePublished - Jun 30 2000

Fingerprint

Limbic System
Long-Term Potentiation
Synapses
Morphine
Seizures
Perforant Pathway
Entorhinal Cortex
Hippocampus
Neuronal Plasticity
Excitatory Postsynaptic Potentials
Tetanus
Street Drugs
N-Methylaspartate
Synaptic Transmission
Opioid Analgesics
Perfusion

Keywords

  • Brain slices
  • Entorhinal cortex
  • Hippocampus
  • Long-term depression
  • Long-term potentiation
  • Prenatal morphine exposure
  • Seizure susceptibility
  • Synaptic plasticity

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Prenatal morphine exposure enhances seizure susceptibility but suppresses long-term potentiation in the limbic system of adult male rats. / Velíšek, Libor; Stanton, Patric K.; Moshe, Solomon L.; Vathy, Ilona.

In: Brain Research, Vol. 869, No. 1-2, 30.06.2000, p. 186-193.

Research output: Contribution to journalArticle

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