Abstract
We examined the effect of prenatal morphine exposure (5-10 mg/kg on days 11-18 of gestation) on seizure susceptibility in female rats during development. The effect of morphine exposure on flurothyl-induced seizures was age-dependent. At postnatal day (PN) 15, morphine exposure decreased both clonic and tonic-clonic seizure thresholds compare to saline controls. At PN 25, morphine exposure did not alter the clonic seizure threshold but increased the threshold to tonic-clonic seizure. At PN 38, morphine exposure did not influence either threshold. The data suggest that the effects of prenatal exposure to opioids on seizures are age-related and transient. Copyright (C) 1999 Elsevier Science B.V.
Original language | English (US) |
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Pages (from-to) | 119-121 |
Number of pages | 3 |
Journal | Developmental Brain Research |
Volume | 116 |
Issue number | 1 |
DOIs | |
State | Published - Aug 5 1999 |
Keywords
- Development
- Epilepsy
- Opioid
- Sex difference
ASJC Scopus subject areas
- Developmental Neuroscience
- Developmental Biology