Prenatal morphine exposure differentially alters seizure susceptibility in developing female rats

Jana Velíšková, Solomon L. Moshé, Ilona Vathy

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We examined the effect of prenatal morphine exposure (5-10 mg/kg on days 11-18 of gestation) on seizure susceptibility in female rats during development. The effect of morphine exposure on flurothyl-induced seizures was age-dependent. At postnatal day (PN) 15, morphine exposure decreased both clonic and tonic-clonic seizure thresholds compare to saline controls. At PN 25, morphine exposure did not alter the clonic seizure threshold but increased the threshold to tonic-clonic seizure. At PN 38, morphine exposure did not influence either threshold. The data suggest that the effects of prenatal exposure to opioids on seizures are age-related and transient. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)119-121
Number of pages3
JournalDevelopmental Brain Research
Issue number1
Publication statusPublished - Aug 5 1999



  • Development
  • Epilepsy
  • Opioid
  • Sex difference

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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