Prenatal morphine exposure differentially alters seizure susceptibility in developing female rats

Jana Velíšková, Solomon L. Moshe, Ilona Vathy

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We examined the effect of prenatal morphine exposure (5-10 mg/kg on days 11-18 of gestation) on seizure susceptibility in female rats during development. The effect of morphine exposure on flurothyl-induced seizures was age-dependent. At postnatal day (PN) 15, morphine exposure decreased both clonic and tonic-clonic seizure thresholds compare to saline controls. At PN 25, morphine exposure did not alter the clonic seizure threshold but increased the threshold to tonic-clonic seizure. At PN 38, morphine exposure did not influence either threshold. The data suggest that the effects of prenatal exposure to opioids on seizures are age-related and transient. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)119-121
Number of pages3
JournalDevelopmental Brain Research
Volume116
Issue number1
DOIs
StatePublished - Aug 5 1999

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Morphine
Seizures
Flurothyl
Opioid Analgesics
Pregnancy

Keywords

  • Development
  • Epilepsy
  • Opioid
  • Sex difference

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Prenatal morphine exposure differentially alters seizure susceptibility in developing female rats. / Velíšková, Jana; Moshe, Solomon L.; Vathy, Ilona.

In: Developmental Brain Research, Vol. 116, No. 1, 05.08.1999, p. 119-121.

Research output: Contribution to journalArticle

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