Prenatal genetic carrier testing using triple disease screening

Christine M. Eng, Clyde B. Schechter, Jane Robinowitz, George Fulop, Tania Burgert, Brynn Levy, Randi Zinberg, Robert J. Desnick

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Context. - Rapid progress in gene discovery has dramatically increased diagnostic capabilities for carrier screening and prenatal testing for genetic diseases. However, simultaneous prenatal carrier screening for prevalent genetic disease has not been evaluated, and patient acceptance and attitudes toward this testing strategy remain undefined. Objective. - To evaluate an educational, counseling, and carrier testing program for 3 genetic disorders: Tay-Sachs disease (TSD), type 1 Gaucher disease (GD), and cystic fibrosis (CF) that differ in detectability, severity, and availability of therapy. Design. - Potential participants received education and genetic counseling, gave informed consent, chose screening tests, and completed pre- education and posteducation questionnaires that assessed knowledge, attitudes toward genetic testing, and disease testing preferences. Setting. - Medical genetics referral center. Patients. - Volunteer sample of 2824 Ashkenazi Jewish individuals enrolled as couples who were referred for TSD testing. Intervention. - Genetic counseling, education, and if chosen, genetic testing for any or all 3 disorders. Main Outcome Measure. - Acceptance of screening for each of the 3 disorders. Secondary outcomes include attitudes toward genetic testing and reproductive considerations. Results. - Of the 2824 individuals tested for TSD, 97% and 95% also chose testing for CF and GD, respectively. The frequency of detected carriers was 1:21 for TSD, 1:25 for CF, and 1:18 for GD. Twenty-one carrier couples were identified, counseled, and all postconception couples opted for prenatal diagnosis. Pre-education and posteducation questionnaires revealed that patients initially knew little about the diseases, but acquired disease information and increased knowledge of genetic concepts. Education and genetic counseling increased understanding and retention of genetic concepts and disease-related information, and minimized test-related anxiety. Although individuals sought screening for all 3 diseases, reproductive attitudes and decisions varied directly with disease severity and treatability. Conclusions. - These findings emphasize the importance of genetic counseling for prenatal carrier testing and may improve understanding, acceptance, and informed decision making for prenatal carrier screening for multiple genetic diseases.

Original languageEnglish (US)
Pages (from-to)1265-1272
Number of pages8
JournalJournal of the American Medical Association
Volume278
Issue number15
StatePublished - Oct 15 1997
Externally publishedYes

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Inborn Genetic Diseases
Genetic Testing
Heterozygote
Tay-Sachs Disease
Genetic Counseling
Prenatal Diagnosis
Gaucher Disease
Education
Genetic Phenomena
Cystic Fibrosis
Medical Genetics
Genetic Association Studies
Cerebral Palsy
Informed Consent
Counseling
Volunteers
Decision Making
Referral and Consultation
Anxiety
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Eng, C. M., Schechter, C. B., Robinowitz, J., Fulop, G., Burgert, T., Levy, B., ... Desnick, R. J. (1997). Prenatal genetic carrier testing using triple disease screening. Journal of the American Medical Association, 278(15), 1265-1272.

Prenatal genetic carrier testing using triple disease screening. / Eng, Christine M.; Schechter, Clyde B.; Robinowitz, Jane; Fulop, George; Burgert, Tania; Levy, Brynn; Zinberg, Randi; Desnick, Robert J.

In: Journal of the American Medical Association, Vol. 278, No. 15, 15.10.1997, p. 1265-1272.

Research output: Contribution to journalArticle

Eng, CM, Schechter, CB, Robinowitz, J, Fulop, G, Burgert, T, Levy, B, Zinberg, R & Desnick, RJ 1997, 'Prenatal genetic carrier testing using triple disease screening', Journal of the American Medical Association, vol. 278, no. 15, pp. 1265-1272.
Eng CM, Schechter CB, Robinowitz J, Fulop G, Burgert T, Levy B et al. Prenatal genetic carrier testing using triple disease screening. Journal of the American Medical Association. 1997 Oct 15;278(15):1265-1272.
Eng, Christine M. ; Schechter, Clyde B. ; Robinowitz, Jane ; Fulop, George ; Burgert, Tania ; Levy, Brynn ; Zinberg, Randi ; Desnick, Robert J. / Prenatal genetic carrier testing using triple disease screening. In: Journal of the American Medical Association. 1997 ; Vol. 278, No. 15. pp. 1265-1272.
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