Prenatal alcohol exposure alters the liver and induces pathological changes in the morphology and function of the Golgi apparatus (GA), including an accumulation or reduced transport of newly synthesized glycoconjugates which suggests that ethanol could affect the cytoskeleton (CSK) in hepatocytes. To test this possibility we have analysed, using various techniques, the effect of ethanol "in utero" on several CSK proteins including actin, α- tubulin, cytokeratin, vimentin and the motor associated proteins dynein and kinesin. Our results show that this treatment increases the amount of both α-tubulin and cytokeratin and alters its distribution.
|Original language||English (US)|
|Journal||International Journal of Developmental Biology|
|Issue number||SUPPL. 1|
|Publication status||Published - Jan 1 2001|
ASJC Scopus subject areas
- Developmental Biology