Prenatal exposure to alcohol affects the cytoskeleton in the developing rat liver

I. Azorin, Francisco Lazaro-Dieguez, J. M. Martinez, M. Portoles, C. Guerri, J. Renau-Piqueras

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Prenatal alcohol exposure alters the liver and induces pathological changes in the morphology and function of the Golgi apparatus (GA), including an accumulation or reduced transport of newly synthesized glycoconjugates which suggests that ethanol could affect the cytoskeleton (CSK) in hepatocytes. To test this possibility we have analysed, using various techniques, the effect of ethanol "in utero" on several CSK proteins including actin, α- tubulin, cytokeratin, vimentin and the motor associated proteins dynein and kinesin. Our results show that this treatment increases the amount of both α-tubulin and cytokeratin and alters its distribution.

Original languageEnglish (US)
JournalInternational Journal of Developmental Biology
Volume45
Issue numberSUPPL. 1
StatePublished - 2001
Externally publishedYes

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Tubulin
Keratins
Cytoskeleton
Ethanol
Alcohols
Dyneins
Kinesin
Glycoconjugates
Liver
Golgi Apparatus
Vimentin
Actins
Hepatocytes
Proteins

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology

Cite this

Azorin, I., Lazaro-Dieguez, F., Martinez, J. M., Portoles, M., Guerri, C., & Renau-Piqueras, J. (2001). Prenatal exposure to alcohol affects the cytoskeleton in the developing rat liver. International Journal of Developmental Biology, 45(SUPPL. 1).

Prenatal exposure to alcohol affects the cytoskeleton in the developing rat liver. / Azorin, I.; Lazaro-Dieguez, Francisco; Martinez, J. M.; Portoles, M.; Guerri, C.; Renau-Piqueras, J.

In: International Journal of Developmental Biology, Vol. 45, No. SUPPL. 1, 2001.

Research output: Contribution to journalArticle

Azorin, I, Lazaro-Dieguez, F, Martinez, JM, Portoles, M, Guerri, C & Renau-Piqueras, J 2001, 'Prenatal exposure to alcohol affects the cytoskeleton in the developing rat liver', International Journal of Developmental Biology, vol. 45, no. SUPPL. 1.
Azorin, I. ; Lazaro-Dieguez, Francisco ; Martinez, J. M. ; Portoles, M. ; Guerri, C. ; Renau-Piqueras, J. / Prenatal exposure to alcohol affects the cytoskeleton in the developing rat liver. In: International Journal of Developmental Biology. 2001 ; Vol. 45, No. SUPPL. 1.
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