Prenatal administration of methadone using the osmotic minipump

Effects on maternal and offspring toxicity, growth, and behavior in the rat

Donald E. Hutchings, Ann Zmitrovich, Stephen C. Brake, Daniel Malowany, Sarah H. Church, Thomas J. Nero

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Two doses of methadone were administered by osmotic minipump from day 8 of gestation through parturition. A pair-fed control group received saline via minipump and was allowed to eat and drink only the amount consumed by the high dose group on the same gestation days. A nontreated control group was left undisturbed during pregnancy. All treated and control litters were fostered at birth to untreated dams. Naloxone challenge of the dams after parturition showed that drug treatment produced physical dependence. Methadone treatment reduced maternal weight gain but had no effect on either the frequency of resorptions or birthweight. Both doses of methadone increased perinatal mortality but only the high dose produced a decrement in postnatal growth. To examine the effects of methadone on the rest-activity cycle of the offspring, groups of three littermates from each of the treated and control groups were tested for an 8 h observation period on electronic activity monitors at 22 days of age. No behavioral effects were observed for either control group or the low dose methadone group. The high dose methadone offspring, however, spent less time resting, showed disrupted rhythmicity, and poor state regulation. These findings are discussed in relation to earlier studies using once per day methadone administration as well as clinical descriptions of infants undergoing opiate abstinence.

Original languageEnglish (US)
Pages (from-to)65-71
Number of pages7
JournalNeurotoxicology and Teratology
Volume14
Issue number1
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Methadone
Toxicity
Rats
Mothers
Growth
Control Groups
Parturition
Pregnancy
Dams
Opiate Alkaloids
Activity Cycles
Drug therapy
Perinatal Mortality
Periodicity
Naloxone
Weight Gain
Observation
Therapeutics
Pharmaceutical Preparations

Keywords

  • Methadone
  • Opioid abstinence
  • Osmotic minipump
  • Prenatal
  • Rat
  • Rest-Activity Cycle

ASJC Scopus subject areas

  • Neuroscience(all)
  • Cellular and Molecular Neuroscience
  • Toxicology

Cite this

Prenatal administration of methadone using the osmotic minipump : Effects on maternal and offspring toxicity, growth, and behavior in the rat. / Hutchings, Donald E.; Zmitrovich, Ann; Brake, Stephen C.; Malowany, Daniel; Church, Sarah H.; Nero, Thomas J.

In: Neurotoxicology and Teratology, Vol. 14, No. 1, 1992, p. 65-71.

Research output: Contribution to journalArticle

Hutchings, Donald E. ; Zmitrovich, Ann ; Brake, Stephen C. ; Malowany, Daniel ; Church, Sarah H. ; Nero, Thomas J. / Prenatal administration of methadone using the osmotic minipump : Effects on maternal and offspring toxicity, growth, and behavior in the rat. In: Neurotoxicology and Teratology. 1992 ; Vol. 14, No. 1. pp. 65-71.
@article{fbcba61faa2d432fbee71ef9fc30312d,
title = "Prenatal administration of methadone using the osmotic minipump: Effects on maternal and offspring toxicity, growth, and behavior in the rat",
abstract = "Two doses of methadone were administered by osmotic minipump from day 8 of gestation through parturition. A pair-fed control group received saline via minipump and was allowed to eat and drink only the amount consumed by the high dose group on the same gestation days. A nontreated control group was left undisturbed during pregnancy. All treated and control litters were fostered at birth to untreated dams. Naloxone challenge of the dams after parturition showed that drug treatment produced physical dependence. Methadone treatment reduced maternal weight gain but had no effect on either the frequency of resorptions or birthweight. Both doses of methadone increased perinatal mortality but only the high dose produced a decrement in postnatal growth. To examine the effects of methadone on the rest-activity cycle of the offspring, groups of three littermates from each of the treated and control groups were tested for an 8 h observation period on electronic activity monitors at 22 days of age. No behavioral effects were observed for either control group or the low dose methadone group. The high dose methadone offspring, however, spent less time resting, showed disrupted rhythmicity, and poor state regulation. These findings are discussed in relation to earlier studies using once per day methadone administration as well as clinical descriptions of infants undergoing opiate abstinence.",
keywords = "Methadone, Opioid abstinence, Osmotic minipump, Prenatal, Rat, Rest-Activity Cycle",
author = "Hutchings, {Donald E.} and Ann Zmitrovich and Brake, {Stephen C.} and Daniel Malowany and Church, {Sarah H.} and Nero, {Thomas J.}",
year = "1992",
doi = "10.1016/0892-0362(92)90030-E",
language = "English (US)",
volume = "14",
pages = "65--71",
journal = "Neurotoxicology and Teratology",
issn = "0892-0362",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Prenatal administration of methadone using the osmotic minipump

T2 - Effects on maternal and offspring toxicity, growth, and behavior in the rat

AU - Hutchings, Donald E.

AU - Zmitrovich, Ann

AU - Brake, Stephen C.

AU - Malowany, Daniel

AU - Church, Sarah H.

AU - Nero, Thomas J.

PY - 1992

Y1 - 1992

N2 - Two doses of methadone were administered by osmotic minipump from day 8 of gestation through parturition. A pair-fed control group received saline via minipump and was allowed to eat and drink only the amount consumed by the high dose group on the same gestation days. A nontreated control group was left undisturbed during pregnancy. All treated and control litters were fostered at birth to untreated dams. Naloxone challenge of the dams after parturition showed that drug treatment produced physical dependence. Methadone treatment reduced maternal weight gain but had no effect on either the frequency of resorptions or birthweight. Both doses of methadone increased perinatal mortality but only the high dose produced a decrement in postnatal growth. To examine the effects of methadone on the rest-activity cycle of the offspring, groups of three littermates from each of the treated and control groups were tested for an 8 h observation period on electronic activity monitors at 22 days of age. No behavioral effects were observed for either control group or the low dose methadone group. The high dose methadone offspring, however, spent less time resting, showed disrupted rhythmicity, and poor state regulation. These findings are discussed in relation to earlier studies using once per day methadone administration as well as clinical descriptions of infants undergoing opiate abstinence.

AB - Two doses of methadone were administered by osmotic minipump from day 8 of gestation through parturition. A pair-fed control group received saline via minipump and was allowed to eat and drink only the amount consumed by the high dose group on the same gestation days. A nontreated control group was left undisturbed during pregnancy. All treated and control litters were fostered at birth to untreated dams. Naloxone challenge of the dams after parturition showed that drug treatment produced physical dependence. Methadone treatment reduced maternal weight gain but had no effect on either the frequency of resorptions or birthweight. Both doses of methadone increased perinatal mortality but only the high dose produced a decrement in postnatal growth. To examine the effects of methadone on the rest-activity cycle of the offspring, groups of three littermates from each of the treated and control groups were tested for an 8 h observation period on electronic activity monitors at 22 days of age. No behavioral effects were observed for either control group or the low dose methadone group. The high dose methadone offspring, however, spent less time resting, showed disrupted rhythmicity, and poor state regulation. These findings are discussed in relation to earlier studies using once per day methadone administration as well as clinical descriptions of infants undergoing opiate abstinence.

KW - Methadone

KW - Opioid abstinence

KW - Osmotic minipump

KW - Prenatal

KW - Rat

KW - Rest-Activity Cycle

UR - http://www.scopus.com/inward/record.url?scp=0026586814&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026586814&partnerID=8YFLogxK

U2 - 10.1016/0892-0362(92)90030-E

DO - 10.1016/0892-0362(92)90030-E

M3 - Article

VL - 14

SP - 65

EP - 71

JO - Neurotoxicology and Teratology

JF - Neurotoxicology and Teratology

SN - 0892-0362

IS - 1

ER -