Premature ovarian failure: A modern approach to diagnosis and treatment

H. Lieman, N. Santoro

Research output: Contribution to journalArticle

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Abstract

Hypergonadotropic hypogonadism or premature ovarian failure is not that uncommon. Approximately 1% of the reproductive age population are affected. The presentation is heterogeneous with a wide variety of etiologies. The multiple causes include autoimmune, genetic, iatrogenic, infection, enzymatic deficiencies, and idiopathic. The mechanism for the lack of ovarian function is poorly understood. The diagnostic approach to these patients requires a detailed history and thorough physical exam to help identify a potential etiology for the disease process. A variety of diagnostic tests can be performed dependent on suspected etiologies. Simple blood tests should be performed to rule out evidence of autoimmune polyglandular failure. A karyotype should be performed in any patient presenting with primary ovarian failure. Treatment has been empiric hormone replacement with estrogen and progesterone. For those patients desiring pregnancy, ovulation induction has not been successful although pregnancies have been reported in the literature. In the age of in vitro fertilization, oocyte donation has become a reality and a successful option for young women who are affected by premature ovarian failure.

LanguageEnglish (US)
Pages314-321
Number of pages8
JournalEndocrinologist
Volume7
Issue number5
StatePublished - 1997
Externally publishedYes

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Primary Ovarian Insufficiency
Oocyte Donation
Pregnancy
Estrogen Replacement Therapy
Hypogonadism
Ovulation Induction
Hematologic Tests
Fertilization in Vitro
Karyotype
Routine Diagnostic Tests
Progesterone
Therapeutics
History
Hormones
Infection
Population

ASJC Scopus subject areas

  • Endocrinology

Cite this

Premature ovarian failure : A modern approach to diagnosis and treatment. / Lieman, H.; Santoro, N.

In: Endocrinologist, Vol. 7, No. 5, 1997, p. 314-321.

Research output: Contribution to journalArticle

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