Preliminary observations on the effect of synthetic thyrotropin releasing factor on plasma thyrotropin levels in man

Norman Fleischer, Roger Burgus, Wylie Vale, Thomas Dunn, Roger Guillemin

Research output: Contribution to journalArticle

113 Scopus citations


Intravenous administration of synthetic TRF in doses of 250-750 µg stimulates a rise in plasma HTSH levels in normal individuals. No rise in plasma HTSH occurs following 500-750 µg of TRF in subjects on 0.3 mg of Lthyroxine or in patients with panhypopituitarism. One of two euthyroid patients with a sella tumor appeared to respond suboptimally to TRF. It is condluded that synthetic TRF is a convenient means for testing the integrity of the human pituitary for TSH secretion.

Original languageEnglish (US)
Pages (from-to)109-112
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Issue number1
Publication statusPublished - Jan 1 1970


ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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