Preliminary observations on the effect of synthetic thyrotropin releasing factor on plasma thyrotropin levels in man

Norman Fleischer; Roger Burgus; Wylie Vale; Thomas Dunn; Roger Guillemin

doi:10.1210/jcem-31-1-109

Preliminary observations on the effect of synthetic thyrotropin releasing factor on plasma thyrotropin levels in man

Norman Fleischer, Roger Burgus, Wylie Vale, Thomas Dunn, Roger Guillemin

Research output: Contribution to journal › Article › peer-review

120 Scopus citations

Abstract

Intravenous administration of synthetic TRF in doses of 250-750 µg stimulates a rise in plasma HTSH levels in normal individuals. No rise in plasma HTSH occurs following 500-750 µg of TRF in subjects on 0.3 mg of Lthyroxine or in patients with panhypopituitarism. One of two euthyroid patients with a sella tumor appeared to respond suboptimally to TRF. It is condluded that synthetic TRF is a convenient means for testing the integrity of the human pituitary for TSH secretion.

Original language	English (US)
Pages (from-to)	109-112
Number of pages	4
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	31
Issue number	1
DOIs	https://doi.org/10.1210/jcem-31-1-109
State	Published - 1970
Externally published	Yes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1210/jcem-31-1-109

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AU - Fleischer, Norman

AU - Burgus, Roger

AU - Vale, Wylie

AU - Dunn, Thomas

AU - Guillemin, Roger

PY - 1970

Y1 - 1970

N2 - Intravenous administration of synthetic TRF in doses of 250-750 µg stimulates a rise in plasma HTSH levels in normal individuals. No rise in plasma HTSH occurs following 500-750 µg of TRF in subjects on 0.3 mg of Lthyroxine or in patients with panhypopituitarism. One of two euthyroid patients with a sella tumor appeared to respond suboptimally to TRF. It is condluded that synthetic TRF is a convenient means for testing the integrity of the human pituitary for TSH secretion.

AB - Intravenous administration of synthetic TRF in doses of 250-750 µg stimulates a rise in plasma HTSH levels in normal individuals. No rise in plasma HTSH occurs following 500-750 µg of TRF in subjects on 0.3 mg of Lthyroxine or in patients with panhypopituitarism. One of two euthyroid patients with a sella tumor appeared to respond suboptimally to TRF. It is condluded that synthetic TRF is a convenient means for testing the integrity of the human pituitary for TSH secretion.

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Preliminary observations on the effect of synthetic thyrotropin releasing factor on plasma thyrotropin levels in man

Abstract

ASJC Scopus subject areas

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