Preliminary observations on the association between serum IL-6 and hydration status and cardiovascular risk in patients treated with peritoneal dialysis

Dorota Sikorska, Krzysztof Pawlaczyk, Magdalena Roszak, Natasza Czepulis, Andrzej Oko, Marek Karczewski, Andrzej Breborowicz, Janusz Witowski

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Introduction Systemic inflammation, as defined by elevated blood IL-6, is a strong independent predictor of peritoneal dialysis (PD) patient survival. The present study has aimed to determine whether there exists a particular “phenotype” associated with high systemic IL-6 that characterizes PD patients in terms of their fluid status and cardiac parameters. Methods Fifty-seven prevalent PD patients were classified according to serum concentrations of IL-6. The degree of overhydration was assessed by bioimpedance analysis (BIA). Echocardiography and serum concentrations of NT-proBNP and troponin T were used to assess cardiovascular risk. Results Patients with high serum IL-6 were older, more often diabetic, treated with PD for longer, and significantly more overhydrated. There was a significant correlation between serum IL-6, hydration status (r = 0.38; p = 0.002) and serum albumin (r = −0.35; p = 0.009). Multivariate regression analysis confirmed a strong association of overhydration, hypoalbuminemia, and systemic IL-6 concentration. Patients with high IL-6 had significantly increased levels of both NT-proBNP (r = 0.36; p = 0.006) and TnT (r = 0.50; p 

Original languageEnglish (US)
Pages (from-to)171-176
Number of pages6
JournalCytokine
Volume85
DOIs
StatePublished - Sep 1 2016
Externally publishedYes

Fingerprint

Dialysis
Peritoneal Dialysis
Hydration
Interleukin-6
Association reactions
Serum
Echocardiography
Hypoalbuminemia
Troponin T
Regression analysis
Serum Albumin
Blood
Multivariate Analysis
Regression Analysis
Inflammation
Phenotype
Fluids
Survival

Keywords

  • Cardiovascular risk
  • IL-6
  • Overhydration

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Hematology
  • Biochemistry
  • Molecular Biology

Cite this

Preliminary observations on the association between serum IL-6 and hydration status and cardiovascular risk in patients treated with peritoneal dialysis. / Sikorska, Dorota; Pawlaczyk, Krzysztof; Roszak, Magdalena; Czepulis, Natasza; Oko, Andrzej; Karczewski, Marek; Breborowicz, Andrzej; Witowski, Janusz.

In: Cytokine, Vol. 85, 01.09.2016, p. 171-176.

Research output: Contribution to journalArticle

Sikorska, D, Pawlaczyk, K, Roszak, M, Czepulis, N, Oko, A, Karczewski, M, Breborowicz, A & Witowski, J 2016, 'Preliminary observations on the association between serum IL-6 and hydration status and cardiovascular risk in patients treated with peritoneal dialysis', Cytokine, vol. 85, pp. 171-176. https://doi.org/10.1016/j.cyto.2016.06.005
Sikorska, Dorota ; Pawlaczyk, Krzysztof ; Roszak, Magdalena ; Czepulis, Natasza ; Oko, Andrzej ; Karczewski, Marek ; Breborowicz, Andrzej ; Witowski, Janusz. / Preliminary observations on the association between serum IL-6 and hydration status and cardiovascular risk in patients treated with peritoneal dialysis. In: Cytokine. 2016 ; Vol. 85. pp. 171-176.
@article{0e5bc95c318f4671b50d9f4197f161cc,
title = "Preliminary observations on the association between serum IL-6 and hydration status and cardiovascular risk in patients treated with peritoneal dialysis",
abstract = "Introduction Systemic inflammation, as defined by elevated blood IL-6, is a strong independent predictor of peritoneal dialysis (PD) patient survival. The present study has aimed to determine whether there exists a particular “phenotype” associated with high systemic IL-6 that characterizes PD patients in terms of their fluid status and cardiac parameters. Methods Fifty-seven prevalent PD patients were classified according to serum concentrations of IL-6. The degree of overhydration was assessed by bioimpedance analysis (BIA). Echocardiography and serum concentrations of NT-proBNP and troponin T were used to assess cardiovascular risk. Results Patients with high serum IL-6 were older, more often diabetic, treated with PD for longer, and significantly more overhydrated. There was a significant correlation between serum IL-6, hydration status (r = 0.38; p = 0.002) and serum albumin (r = −0.35; p = 0.009). Multivariate regression analysis confirmed a strong association of overhydration, hypoalbuminemia, and systemic IL-6 concentration. Patients with high IL-6 had significantly increased levels of both NT-proBNP (r = 0.36; p = 0.006) and TnT (r = 0.50; p ",
keywords = "Cardiovascular risk, IL-6, Overhydration",
author = "Dorota Sikorska and Krzysztof Pawlaczyk and Magdalena Roszak and Natasza Czepulis and Andrzej Oko and Marek Karczewski and Andrzej Breborowicz and Janusz Witowski",
year = "2016",
month = "9",
day = "1",
doi = "10.1016/j.cyto.2016.06.005",
language = "English (US)",
volume = "85",
pages = "171--176",
journal = "Cytokine",
issn = "1043-4666",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Preliminary observations on the association between serum IL-6 and hydration status and cardiovascular risk in patients treated with peritoneal dialysis

AU - Sikorska, Dorota

AU - Pawlaczyk, Krzysztof

AU - Roszak, Magdalena

AU - Czepulis, Natasza

AU - Oko, Andrzej

AU - Karczewski, Marek

AU - Breborowicz, Andrzej

AU - Witowski, Janusz

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Introduction Systemic inflammation, as defined by elevated blood IL-6, is a strong independent predictor of peritoneal dialysis (PD) patient survival. The present study has aimed to determine whether there exists a particular “phenotype” associated with high systemic IL-6 that characterizes PD patients in terms of their fluid status and cardiac parameters. Methods Fifty-seven prevalent PD patients were classified according to serum concentrations of IL-6. The degree of overhydration was assessed by bioimpedance analysis (BIA). Echocardiography and serum concentrations of NT-proBNP and troponin T were used to assess cardiovascular risk. Results Patients with high serum IL-6 were older, more often diabetic, treated with PD for longer, and significantly more overhydrated. There was a significant correlation between serum IL-6, hydration status (r = 0.38; p = 0.002) and serum albumin (r = −0.35; p = 0.009). Multivariate regression analysis confirmed a strong association of overhydration, hypoalbuminemia, and systemic IL-6 concentration. Patients with high IL-6 had significantly increased levels of both NT-proBNP (r = 0.36; p = 0.006) and TnT (r = 0.50; p 

AB - Introduction Systemic inflammation, as defined by elevated blood IL-6, is a strong independent predictor of peritoneal dialysis (PD) patient survival. The present study has aimed to determine whether there exists a particular “phenotype” associated with high systemic IL-6 that characterizes PD patients in terms of their fluid status and cardiac parameters. Methods Fifty-seven prevalent PD patients were classified according to serum concentrations of IL-6. The degree of overhydration was assessed by bioimpedance analysis (BIA). Echocardiography and serum concentrations of NT-proBNP and troponin T were used to assess cardiovascular risk. Results Patients with high serum IL-6 were older, more often diabetic, treated with PD for longer, and significantly more overhydrated. There was a significant correlation between serum IL-6, hydration status (r = 0.38; p = 0.002) and serum albumin (r = −0.35; p = 0.009). Multivariate regression analysis confirmed a strong association of overhydration, hypoalbuminemia, and systemic IL-6 concentration. Patients with high IL-6 had significantly increased levels of both NT-proBNP (r = 0.36; p = 0.006) and TnT (r = 0.50; p 

KW - Cardiovascular risk

KW - IL-6

KW - Overhydration

UR - http://www.scopus.com/inward/record.url?scp=84976537497&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84976537497&partnerID=8YFLogxK

U2 - 10.1016/j.cyto.2016.06.005

DO - 10.1016/j.cyto.2016.06.005

M3 - Article

AN - SCOPUS:84976537497

VL - 85

SP - 171

EP - 176

JO - Cytokine

JF - Cytokine

SN - 1043-4666

ER -