Preleukemic and leukemic evolution at the stem cell level

Research output: Contribution to journalReview articlepeer-review

Abstract

Hematological malignancies are an aggregate of diverse populations of cells that arise following a complex process of clonal evolution and selection. Recent approaches have facilitated the study of clonal populations and their evolution over time across multiple phenotypic cell populations. In this review, we present current concepts on the role of clonal evolution in leukemic initiation, disease progression, and relapse. We highlight recent advances and unanswered questions about the contribution of the hematopoietic stem cell population to these processes.

Original languageEnglish (US)
Pages (from-to)1013-1018
Number of pages6
JournalBlood
Volume137
Issue number8
DOIs
StatePublished - Feb 25 2021

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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