TY - JOUR
T1 - Prehypertension in Early Pregnancy
T2 - What is the Significance?
AU - Rosner, Jonathan Y.
AU - Gutierrez, Megan
AU - Dziadosz, Margaret
AU - Pham, Amelie
AU - Bennett, Terri Ann
AU - Dolin, Cara
AU - Herbst, Allyson
AU - Lee, Sarah
AU - Roman, Ashley S.
PY - 2016/5/15
Y1 - 2016/5/15
N2 - Objective Hypertensive disorders play a significant role in maternal morbidity and mortality. There is limited data on prehypertension (pre-HTN) during the first half of pregnancy. We sought to examine the risk of adverse pregnancy outcomes in patients with prehypertension in early pregnancy (2, Fisher's Exact, Student t-test, and Mann–Whitney U test with p <0.05 used as significance. Results Patients with pre-HTN delivered earlier (38.8 ± 1.9 weeks vs 39.3 ± 1.7 weeks), had more pregnancy related hypertension (odds ratio [OR], 4.62; confidence interval [CI], 2.30–9.25; p <0.01) and composite maternal adverse outcomes (OR, 2. 10; 95% CI, 1.30–3.41; p <0.01), NICU admission (OR, 2.21; 95% CI, 1.14–4.26; p = 0.02), neonatal sepsis (OR, 6.12; 95% CI, 2.23–16.82; p <0.01), and composite neonatal adverse outcomes (OR, 2.05; 95% CI, 1.20–3.49; p <0.01). Conclusion Although women with pre-HTN are currently classified as normal in obstetrics, they are more similar to women with CHTN. Pre-HTN in the first half of pregnancy increases the likelihood of adverse outcomes.
AB - Objective Hypertensive disorders play a significant role in maternal morbidity and mortality. There is limited data on prehypertension (pre-HTN) during the first half of pregnancy. We sought to examine the risk of adverse pregnancy outcomes in patients with prehypertension in early pregnancy (2, Fisher's Exact, Student t-test, and Mann–Whitney U test with p <0.05 used as significance. Results Patients with pre-HTN delivered earlier (38.8 ± 1.9 weeks vs 39.3 ± 1.7 weeks), had more pregnancy related hypertension (odds ratio [OR], 4.62; confidence interval [CI], 2.30–9.25; p <0.01) and composite maternal adverse outcomes (OR, 2. 10; 95% CI, 1.30–3.41; p <0.01), NICU admission (OR, 2.21; 95% CI, 1.14–4.26; p = 0.02), neonatal sepsis (OR, 6.12; 95% CI, 2.23–16.82; p <0.01), and composite neonatal adverse outcomes (OR, 2.05; 95% CI, 1.20–3.49; p <0.01). Conclusion Although women with pre-HTN are currently classified as normal in obstetrics, they are more similar to women with CHTN. Pre-HTN in the first half of pregnancy increases the likelihood of adverse outcomes.
KW - adverse outcomes
KW - hypertension
KW - maternal outcomes
KW - neonatal outcomes
KW - pregnancy
KW - prehypertension
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U2 - 10.1055/s-0036-1584542
DO - 10.1055/s-0036-1584542
M3 - Article
C2 - 27322669
AN - SCOPUS:84975517113
SN - 0735-1631
JO - American Journal of Perinatology
JF - American Journal of Perinatology
ER -