Prehypertension in Early Pregnancy: What is the Significance?

Jonathan Y. Rosner, Megan Gutierrez, Margaret Dziadosz, Amelie Pham, Terri Ann Bennett, Cara Dolin, Allyson Herbst, Sarah Lee, Ashley S. Roman

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Objective Hypertensive disorders play a significant role in maternal morbidity and mortality. There is limited data on prehypertension (pre-HTN) during the first half of pregnancy. We sought to examine the risk of adverse pregnancy outcomes in patients with prehypertension in early pregnancy (2, Fisher's Exact, Student t-test, and Mann–Whitney U test with p <0.05 used as significance. Results Patients with pre-HTN delivered earlier (38.8 ± 1.9 weeks vs 39.3 ± 1.7 weeks), had more pregnancy related hypertension (odds ratio [OR], 4.62; confidence interval [CI], 2.30–9.25; p <0.01) and composite maternal adverse outcomes (OR, 2. 10; 95% CI, 1.30–3.41; p <0.01), NICU admission (OR, 2.21; 95% CI, 1.14–4.26; p = 0.02), neonatal sepsis (OR, 6.12; 95% CI, 2.23–16.82; p <0.01), and composite neonatal adverse outcomes (OR, 2.05; 95% CI, 1.20–3.49; p <0.01). Conclusion Although women with pre-HTN are currently classified as normal in obstetrics, they are more similar to women with CHTN. Pre-HTN in the first half of pregnancy increases the likelihood of adverse outcomes.

Original languageEnglish (US)
JournalAmerican Journal of Perinatology
StateAccepted/In press - May 15 2016


  • adverse outcomes
  • hypertension
  • maternal outcomes
  • neonatal outcomes
  • pregnancy
  • prehypertension

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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