Pregnane X receptor activation triggers rapid ATP release in primed macrophages that mediates NLRP3 inflammasome activation

Grace Hudson, Kyle L. Flannigan, Vivek Krishna Pulakazhi Venu, Laurie Alston, Christina F. Sandall, Justin A. MacDonald, Daniel A. Muruve, Thomas K.H. Chang, Sridhar Mani, Simon A. Hirota

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Medicine & Life Sciences