Pregnancy-related events associated with subclinical cardiovascular disease burden in late midlife: SWAN

Yamnia I. Cortés, Janet M. Catov, Maria Brooks, Samar R. El Khoudary, Rebecca C. Thurston, Karen A. Matthews, Carmen R. Isasi, Elizabeth A. Jackson, Emma Barinas-Mitchell

Research output: Contribution to journalArticle

Abstract

Background and aims: Reproductive factors are associated with later life CVD in women (e.g., age at first birth, preeclampsia, gestational diabetes), but studies have focused largely on premenopausal women. We examined the relationship of reproductive factors with subclinical CVD burden in late midlife women. Methods: We included 964 parous women from the Study of Women's Health Across the Nation (SWAN), who completed a reproductive history questionnaire at the 13th SWAN visit (2011–2012), and a carotid ultrasound and brachial-ankle pulse wave velocity (baPWV) assessment. The primary outcomes were carotid intima-media thickness, plaque, and baPWV; our secondary outcome was a composite subclinical CVD index created using these measures. Linear and logistic regression was performed to examine associations with individual subclinical CVD measures, and multinomial logistic regression was used in analyses of the composite index. Models adjusted for socio-demographics and cardiovascular risk factors. Results: Mean age at subclinical CVD assessment was 60.2 years (SD ± 2.7). History of gestational hypertension/preeclampsia was associated with greater carotid IMT (β: 0.038, p = 0.004). Earlier age at first birth was associated with subclinical CVD, but not when accounting for CVD risk factors. History of gestational diabetes was associated with greater baPWV, but not related to our composite index. Conclusions: Pregnancy history is an important marker of subclinical CVD in late midlife and may impact the vasculature through distinct pathways. Future studies are necessary to evaluate racial/ethnic differences in the observed associations and to assess the benefit of a composite subclinical CVD index for earlier CVD risk modification in midlife women.

Original languageEnglish (US)
Pages (from-to)27-35
Number of pages9
JournalAtherosclerosis
Volume289
DOIs
StatePublished - Oct 1 2019

Fingerprint

Women's Health
Cardiovascular Diseases
Pulse Wave Analysis
Pregnancy
Ankle
Reproductive History
Birth Order
Arm
Gestational Diabetes
Pre-Eclampsia
Logistic Models
Pregnancy Induced Hypertension
Carotid Intima-Media Thickness
Linear Models
Demography

Keywords

  • Cardiovascular disease
  • Midlife
  • Reproductive history
  • Subclinical atherosclerosis
  • Women's health

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Cortés, Y. I., Catov, J. M., Brooks, M., El Khoudary, S. R., Thurston, R. C., Matthews, K. A., ... Barinas-Mitchell, E. (2019). Pregnancy-related events associated with subclinical cardiovascular disease burden in late midlife: SWAN. Atherosclerosis, 289, 27-35. https://doi.org/10.1016/j.atherosclerosis.2019.07.012

Pregnancy-related events associated with subclinical cardiovascular disease burden in late midlife : SWAN. / Cortés, Yamnia I.; Catov, Janet M.; Brooks, Maria; El Khoudary, Samar R.; Thurston, Rebecca C.; Matthews, Karen A.; Isasi, Carmen R.; Jackson, Elizabeth A.; Barinas-Mitchell, Emma.

In: Atherosclerosis, Vol. 289, 01.10.2019, p. 27-35.

Research output: Contribution to journalArticle

Cortés, YI, Catov, JM, Brooks, M, El Khoudary, SR, Thurston, RC, Matthews, KA, Isasi, CR, Jackson, EA & Barinas-Mitchell, E 2019, 'Pregnancy-related events associated with subclinical cardiovascular disease burden in late midlife: SWAN', Atherosclerosis, vol. 289, pp. 27-35. https://doi.org/10.1016/j.atherosclerosis.2019.07.012
Cortés, Yamnia I. ; Catov, Janet M. ; Brooks, Maria ; El Khoudary, Samar R. ; Thurston, Rebecca C. ; Matthews, Karen A. ; Isasi, Carmen R. ; Jackson, Elizabeth A. ; Barinas-Mitchell, Emma. / Pregnancy-related events associated with subclinical cardiovascular disease burden in late midlife : SWAN. In: Atherosclerosis. 2019 ; Vol. 289. pp. 27-35.
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abstract = "Background and aims: Reproductive factors are associated with later life CVD in women (e.g., age at first birth, preeclampsia, gestational diabetes), but studies have focused largely on premenopausal women. We examined the relationship of reproductive factors with subclinical CVD burden in late midlife women. Methods: We included 964 parous women from the Study of Women's Health Across the Nation (SWAN), who completed a reproductive history questionnaire at the 13th SWAN visit (2011–2012), and a carotid ultrasound and brachial-ankle pulse wave velocity (baPWV) assessment. The primary outcomes were carotid intima-media thickness, plaque, and baPWV; our secondary outcome was a composite subclinical CVD index created using these measures. Linear and logistic regression was performed to examine associations with individual subclinical CVD measures, and multinomial logistic regression was used in analyses of the composite index. Models adjusted for socio-demographics and cardiovascular risk factors. Results: Mean age at subclinical CVD assessment was 60.2 years (SD ± 2.7). History of gestational hypertension/preeclampsia was associated with greater carotid IMT (β: 0.038, p = 0.004). Earlier age at first birth was associated with subclinical CVD, but not when accounting for CVD risk factors. History of gestational diabetes was associated with greater baPWV, but not related to our composite index. Conclusions: Pregnancy history is an important marker of subclinical CVD in late midlife and may impact the vasculature through distinct pathways. Future studies are necessary to evaluate racial/ethnic differences in the observed associations and to assess the benefit of a composite subclinical CVD index for earlier CVD risk modification in midlife women.",
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T1 - Pregnancy-related events associated with subclinical cardiovascular disease burden in late midlife

T2 - SWAN

AU - Cortés, Yamnia I.

AU - Catov, Janet M.

AU - Brooks, Maria

AU - El Khoudary, Samar R.

AU - Thurston, Rebecca C.

AU - Matthews, Karen A.

AU - Isasi, Carmen R.

AU - Jackson, Elizabeth A.

AU - Barinas-Mitchell, Emma

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N2 - Background and aims: Reproductive factors are associated with later life CVD in women (e.g., age at first birth, preeclampsia, gestational diabetes), but studies have focused largely on premenopausal women. We examined the relationship of reproductive factors with subclinical CVD burden in late midlife women. Methods: We included 964 parous women from the Study of Women's Health Across the Nation (SWAN), who completed a reproductive history questionnaire at the 13th SWAN visit (2011–2012), and a carotid ultrasound and brachial-ankle pulse wave velocity (baPWV) assessment. The primary outcomes were carotid intima-media thickness, plaque, and baPWV; our secondary outcome was a composite subclinical CVD index created using these measures. Linear and logistic regression was performed to examine associations with individual subclinical CVD measures, and multinomial logistic regression was used in analyses of the composite index. Models adjusted for socio-demographics and cardiovascular risk factors. Results: Mean age at subclinical CVD assessment was 60.2 years (SD ± 2.7). History of gestational hypertension/preeclampsia was associated with greater carotid IMT (β: 0.038, p = 0.004). Earlier age at first birth was associated with subclinical CVD, but not when accounting for CVD risk factors. History of gestational diabetes was associated with greater baPWV, but not related to our composite index. Conclusions: Pregnancy history is an important marker of subclinical CVD in late midlife and may impact the vasculature through distinct pathways. Future studies are necessary to evaluate racial/ethnic differences in the observed associations and to assess the benefit of a composite subclinical CVD index for earlier CVD risk modification in midlife women.

AB - Background and aims: Reproductive factors are associated with later life CVD in women (e.g., age at first birth, preeclampsia, gestational diabetes), but studies have focused largely on premenopausal women. We examined the relationship of reproductive factors with subclinical CVD burden in late midlife women. Methods: We included 964 parous women from the Study of Women's Health Across the Nation (SWAN), who completed a reproductive history questionnaire at the 13th SWAN visit (2011–2012), and a carotid ultrasound and brachial-ankle pulse wave velocity (baPWV) assessment. The primary outcomes were carotid intima-media thickness, plaque, and baPWV; our secondary outcome was a composite subclinical CVD index created using these measures. Linear and logistic regression was performed to examine associations with individual subclinical CVD measures, and multinomial logistic regression was used in analyses of the composite index. Models adjusted for socio-demographics and cardiovascular risk factors. Results: Mean age at subclinical CVD assessment was 60.2 years (SD ± 2.7). History of gestational hypertension/preeclampsia was associated with greater carotid IMT (β: 0.038, p = 0.004). Earlier age at first birth was associated with subclinical CVD, but not when accounting for CVD risk factors. History of gestational diabetes was associated with greater baPWV, but not related to our composite index. Conclusions: Pregnancy history is an important marker of subclinical CVD in late midlife and may impact the vasculature through distinct pathways. Future studies are necessary to evaluate racial/ethnic differences in the observed associations and to assess the benefit of a composite subclinical CVD index for earlier CVD risk modification in midlife women.

KW - Cardiovascular disease

KW - Midlife

KW - Reproductive history

KW - Subclinical atherosclerosis

KW - Women's health

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