Pregnancy: Placental isoferritin patterns during normal first trimester and tubal gestations

Ron Maymon, Pe'er Dar, Yoram Manor, Ian Bukovsky, Chaya Moroz

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Placental isoferritin (PLF) has been shown to be involved in the down-regulation of the maternal immune system during pregnancy. In a prospective study, serum PLF concentrations were measured in 33 pregnant women with singleton, normal, ongoing first trimester gestations and compared with those of 22 women with tubal gestations. Diagnoses were based on endocrinological, sonographic, intra-operative and histopathological criteria. Venous blood was obtained from both groups for PLF determination before evacuation of the pregnancy products. B-Human chorionic gonadotrophin (HCG), 17B-oestradiol and progesterone were determined at surgery for the tubal pregnancy patients. The mean ± SD PLF concentrations were 18 ± 14, 25.4 ± 42.3 IU/ml among normal and tubal gestations respectively. Significant differences between normal and tubal pregnancies were found (P < 0.05). Based on PLF measurements, sensitivity (67%) and specificity (33%) values were found to be similar for the normal and ectopic pregnancies. No correlation was found between the other measured pregnancy hormones and PLF for the tubal pregnancy group. Low PLF concentrations among pathological gestations may reflect abnormal trophoblastic activity. The simultaneous assessment of PLF and β-HCG concentrations which probably originate from different trophoblastic cells, is recommended for better diagnosis and monitoring of first trimester placental activity.

Original languageEnglish (US)
Pages (from-to)2445-2447
Number of pages3
JournalHuman Reproduction
Volume10
Issue number9
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

Fingerprint

First Pregnancy Trimester
Ferritins
Pregnancy
Tubal Pregnancy
Chorionic Gonadotropin
Placental Hormones
Ectopic Pregnancy
Progesterone
Pregnant Women
Estradiol
Immune System
Down-Regulation
Mothers
Prospective Studies
Sensitivity and Specificity
Serum

Keywords

  • Ectopic pregnancy
  • Normal pregnancy
  • Placental ferritin

ASJC Scopus subject areas

  • Reproductive Medicine
  • Rehabilitation
  • Obstetrics and Gynecology

Cite this

Pregnancy : Placental isoferritin patterns during normal first trimester and tubal gestations. / Maymon, Ron; Dar, Pe'er; Manor, Yoram; Bukovsky, Ian; Moroz, Chaya.

In: Human Reproduction, Vol. 10, No. 9, 01.01.1995, p. 2445-2447.

Research output: Contribution to journalArticle

Maymon, Ron ; Dar, Pe'er ; Manor, Yoram ; Bukovsky, Ian ; Moroz, Chaya. / Pregnancy : Placental isoferritin patterns during normal first trimester and tubal gestations. In: Human Reproduction. 1995 ; Vol. 10, No. 9. pp. 2445-2447.
@article{e55b7a102fff4de7bd4908b2a9460005,
title = "Pregnancy: Placental isoferritin patterns during normal first trimester and tubal gestations",
abstract = "Placental isoferritin (PLF) has been shown to be involved in the down-regulation of the maternal immune system during pregnancy. In a prospective study, serum PLF concentrations were measured in 33 pregnant women with singleton, normal, ongoing first trimester gestations and compared with those of 22 women with tubal gestations. Diagnoses were based on endocrinological, sonographic, intra-operative and histopathological criteria. Venous blood was obtained from both groups for PLF determination before evacuation of the pregnancy products. B-Human chorionic gonadotrophin (HCG), 17B-oestradiol and progesterone were determined at surgery for the tubal pregnancy patients. The mean ± SD PLF concentrations were 18 ± 14, 25.4 ± 42.3 IU/ml among normal and tubal gestations respectively. Significant differences between normal and tubal pregnancies were found (P < 0.05). Based on PLF measurements, sensitivity (67{\%}) and specificity (33{\%}) values were found to be similar for the normal and ectopic pregnancies. No correlation was found between the other measured pregnancy hormones and PLF for the tubal pregnancy group. Low PLF concentrations among pathological gestations may reflect abnormal trophoblastic activity. The simultaneous assessment of PLF and β-HCG concentrations which probably originate from different trophoblastic cells, is recommended for better diagnosis and monitoring of first trimester placental activity.",
keywords = "Ectopic pregnancy, Normal pregnancy, Placental ferritin",
author = "Ron Maymon and Pe'er Dar and Yoram Manor and Ian Bukovsky and Chaya Moroz",
year = "1995",
month = "1",
day = "1",
doi = "10.1093/oxfordjournals.humrep.a136316",
language = "English (US)",
volume = "10",
pages = "2445--2447",
journal = "Human reproduction (Oxford, England)",
issn = "0268-1161",
publisher = "Oxford University Press",
number = "9",

}

TY - JOUR

T1 - Pregnancy

T2 - Placental isoferritin patterns during normal first trimester and tubal gestations

AU - Maymon, Ron

AU - Dar, Pe'er

AU - Manor, Yoram

AU - Bukovsky, Ian

AU - Moroz, Chaya

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Placental isoferritin (PLF) has been shown to be involved in the down-regulation of the maternal immune system during pregnancy. In a prospective study, serum PLF concentrations were measured in 33 pregnant women with singleton, normal, ongoing first trimester gestations and compared with those of 22 women with tubal gestations. Diagnoses were based on endocrinological, sonographic, intra-operative and histopathological criteria. Venous blood was obtained from both groups for PLF determination before evacuation of the pregnancy products. B-Human chorionic gonadotrophin (HCG), 17B-oestradiol and progesterone were determined at surgery for the tubal pregnancy patients. The mean ± SD PLF concentrations were 18 ± 14, 25.4 ± 42.3 IU/ml among normal and tubal gestations respectively. Significant differences between normal and tubal pregnancies were found (P < 0.05). Based on PLF measurements, sensitivity (67%) and specificity (33%) values were found to be similar for the normal and ectopic pregnancies. No correlation was found between the other measured pregnancy hormones and PLF for the tubal pregnancy group. Low PLF concentrations among pathological gestations may reflect abnormal trophoblastic activity. The simultaneous assessment of PLF and β-HCG concentrations which probably originate from different trophoblastic cells, is recommended for better diagnosis and monitoring of first trimester placental activity.

AB - Placental isoferritin (PLF) has been shown to be involved in the down-regulation of the maternal immune system during pregnancy. In a prospective study, serum PLF concentrations were measured in 33 pregnant women with singleton, normal, ongoing first trimester gestations and compared with those of 22 women with tubal gestations. Diagnoses were based on endocrinological, sonographic, intra-operative and histopathological criteria. Venous blood was obtained from both groups for PLF determination before evacuation of the pregnancy products. B-Human chorionic gonadotrophin (HCG), 17B-oestradiol and progesterone were determined at surgery for the tubal pregnancy patients. The mean ± SD PLF concentrations were 18 ± 14, 25.4 ± 42.3 IU/ml among normal and tubal gestations respectively. Significant differences between normal and tubal pregnancies were found (P < 0.05). Based on PLF measurements, sensitivity (67%) and specificity (33%) values were found to be similar for the normal and ectopic pregnancies. No correlation was found between the other measured pregnancy hormones and PLF for the tubal pregnancy group. Low PLF concentrations among pathological gestations may reflect abnormal trophoblastic activity. The simultaneous assessment of PLF and β-HCG concentrations which probably originate from different trophoblastic cells, is recommended for better diagnosis and monitoring of first trimester placental activity.

KW - Ectopic pregnancy

KW - Normal pregnancy

KW - Placental ferritin

UR - http://www.scopus.com/inward/record.url?scp=0028823071&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028823071&partnerID=8YFLogxK

U2 - 10.1093/oxfordjournals.humrep.a136316

DO - 10.1093/oxfordjournals.humrep.a136316

M3 - Article

C2 - 8530683

AN - SCOPUS:0028823071

VL - 10

SP - 2445

EP - 2447

JO - Human reproduction (Oxford, England)

JF - Human reproduction (Oxford, England)

SN - 0268-1161

IS - 9

ER -