Pregnancy in sensitized kidney transplant recipients: a single-center experience

Maria Ajaimy, Michelle Lubetzky, Timothy Jones, Layla Kamal, Adriana Colovai, Graciela de Boccardo, Enver Akalin

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Background: We aimed to examine the clinical outcomes of sensitized pregnant kidney transplant recipients. Methods: A retrospective cohort study of female patients who received kidney transplant at Montefiore transplant center between June 1, 2009 through December 31, 2014 and had a documented pregnancy in our system. Results: We found that 11 women had pregnancies during this period with a median age of 36 yr (range 22, 39). Pregnancies occurred at a median of 3.1 yr (1.1, 8.7) after transplantation. Pre-pregnancy patients’ median serum creatinine levels and spot urine protein/creatinine ratio were 1.1 mg/dL (1.1, 2.1) and 0.55 g/d (0, 1.2), respectively. Eight patients were sensitized with panel reactive antibody (PRA) levels > 0% and three had PRA of 0%. The sensitized group had a higher incidence of adverse pregnancy outcomes; one stillbirth and two second trimester miscarriage. During a median follow-up of 2.3 yr (1.2, 4) after delivery, three high PRA patients (37%) developed antibody-mediated rejection that led to graft loss. Conclusions: We observed an increased risk of rejection, graft loss, and adverse pregnancy outcomes in sensitized kidney recipients.

Original languageEnglish (US)
Pages (from-to)791-795
Number of pages5
JournalClinical Transplantation
Volume30
Issue number7
DOIs
StatePublished - Jul 1 2016

Keywords

  • fetal outcomes
  • kidney transplant
  • pregnancy
  • rejection

ASJC Scopus subject areas

  • Transplantation

Fingerprint Dive into the research topics of 'Pregnancy in sensitized kidney transplant recipients: a single-center experience'. Together they form a unique fingerprint.

  • Cite this