Abstract
Background: We aimed to examine the clinical outcomes of sensitized pregnant kidney transplant recipients. Methods: A retrospective cohort study of female patients who received kidney transplant at Montefiore transplant center between June 1, 2009 through December 31, 2014 and had a documented pregnancy in our system. Results: We found that 11 women had pregnancies during this period with a median age of 36 yr (range 22, 39). Pregnancies occurred at a median of 3.1 yr (1.1, 8.7) after transplantation. Pre-pregnancy patients’ median serum creatinine levels and spot urine protein/creatinine ratio were 1.1 mg/dL (1.1, 2.1) and 0.55 g/d (0, 1.2), respectively. Eight patients were sensitized with panel reactive antibody (PRA) levels > 0% and three had PRA of 0%. The sensitized group had a higher incidence of adverse pregnancy outcomes; one stillbirth and two second trimester miscarriage. During a median follow-up of 2.3 yr (1.2, 4) after delivery, three high PRA patients (37%) developed antibody-mediated rejection that led to graft loss. Conclusions: We observed an increased risk of rejection, graft loss, and adverse pregnancy outcomes in sensitized kidney recipients.
Original language | English (US) |
---|---|
Pages (from-to) | 791-795 |
Number of pages | 5 |
Journal | Clinical Transplantation |
Volume | 30 |
Issue number | 7 |
DOIs | |
State | Published - Jul 1 2016 |
Keywords
- fetal outcomes
- kidney transplant
- pregnancy
- rejection
ASJC Scopus subject areas
- Transplantation