Prefrontal-subcortical dissociations underlying inhibitory control revealed by event-related fMRI

A. M Clare Kelly, Robert Hester, Kevin Murphy, Daniel C. Javitt, John J. Foxe, Hugh Garavan

Research output: Contribution to journalArticle

152 Citations (Scopus)

Abstract

Using event-related fMRI, this study investigated the neural dynamics of response inhibition under fluctuating task demands. Fourteen participants performed a GO/NOGO task requiring inhibition of a prepotent motor response to NOGO events that occurred as part of either a Fast or Slow presentation stream of GO stimuli. We compared functional activations associated with correct withholds (Stops) required during the Fast presentation stream of stimuli to Stops required during the Slow presentation stream. A predominantly right hemispheric network was activated across conditions, consistent with previous studies. Furthermore, a functional dissociation of activations between conditions was observed. Slow Stops elicited additional activation in anterior dorsal and polar prefrontal cortex and left inferior parietal cortex. Fast Stops showed additional activation in a network that included right dorsolateral prefrontal cortex, insula and dorsal striatum. These results are discussed in terms of our understanding of the impact of preparation on the distributed network underlying response inhibition and the contribution of subcortical areas, such as the basal ganglia, to executive control processes.

Original languageEnglish (US)
Pages (from-to)3105-3112
Number of pages8
JournalEuropean Journal of Neuroscience
Volume19
Issue number11
DOIs
StatePublished - Jun 2004
Externally publishedYes

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Magnetic Resonance Imaging
Prefrontal Cortex
Parietal Lobe
Executive Function
Basal Ganglia
Inhibition (Psychology)

Keywords

  • Basal ganglia
  • Executive functions
  • Functional neuroimaging
  • Inhibition
  • Prefrontal cortex

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Prefrontal-subcortical dissociations underlying inhibitory control revealed by event-related fMRI. / Kelly, A. M Clare; Hester, Robert; Murphy, Kevin; Javitt, Daniel C.; Foxe, John J.; Garavan, Hugh.

In: European Journal of Neuroscience, Vol. 19, No. 11, 06.2004, p. 3105-3112.

Research output: Contribution to journalArticle

Kelly, A. M Clare ; Hester, Robert ; Murphy, Kevin ; Javitt, Daniel C. ; Foxe, John J. ; Garavan, Hugh. / Prefrontal-subcortical dissociations underlying inhibitory control revealed by event-related fMRI. In: European Journal of Neuroscience. 2004 ; Vol. 19, No. 11. pp. 3105-3112.
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