Preferential expansion of autoreactive T lymphocytes from the memory T-cell pool by IL-7

Bibiana Bielekova, Paolo A. Muraro, Ladan Golestaneh, Jeanick Pascal, Henry F. McFarland, Roland Martin

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

We have developed a new technique that allows us to quantify antigen-specific T cells, and to determine their functional phenotype and origin from naive versus memory populations. Using this methodology, we have characterized a total of 286 T-cell lines specific for myelin basic protein (MBP) and influenza hemagglutinin from 16 multiple sclerosis (MS) patients and nine healthy donors. Our data support the notion that MBP-specific T cells undergo in vivo activation in MS patients and indicate a presence of immune dysregulation that renders MS patients prone to develop autoimmunity. Our methodology offers a way to study antigen-specific T-cell characteristics as a surrogate marker in immunotherapy trials. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)115-123
Number of pages9
JournalJournal of Neuroimmunology
Volume100
Issue number1-2
DOIs
StatePublished - Dec 1 1999
Externally publishedYes

Keywords

  • Antigen-specific T cells
  • Interleukin-7
  • Multiple sclerosis
  • Primary proliferation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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