TY - JOUR
T1 - Predictors of virologic success in patients completing a structured antiretroviral adherence program
AU - DeFino, Maryrose
AU - Clark, Jesse
AU - Mogyoros, Daniel
AU - Shuter, Jonathan
N1 - Funding Information:
This work was supported by Award CO15246 from the New York State Department of Health/AIDS Institute Treatment Adherence Demonstration Project. This work was presented in part at the 39th annual meeting of the Infectious Diseases Society of America, October 25-28, 2001, San Francisco. The authors would like to acknowledge Dr. Karl Heiner of SUNY New Paltz for his assistance with the statistical analyses. The authors also thank the Adherence Counselors—Aaron Diaz, Ernestine Lewis, and Norma Cordero—and the Adherence Buddies for the contributions and dedication to our patients.
PY - 2004
Y1 - 2004
N2 - This study describes the effects of a structured, educational/motivational antiretroviral adherence program on virologic and immunologic parameters in HIV-infected patients. Patients were referred because of either self- or provider-identified barriers to adherence. All patients completed 6 to 8 weekly sessions with a nurse or adherence counselor, followed by four quarterly sessions. Sessions included an adherence assessment, individualized patient education, review of adherence strategies, motivational messages, anticipatory planning, and adherence tools. The 58 patients had a mean enrollment CD4 + count of 223 cells/mm3 and mean viral load of 196,454 copies/ml. At the last follow-up, the mean CD4+ count increased to 308 cells/mm3 (p < .001), and mean viral load decreased to 43,309 (p < .001). Thirty (51.7%) patients achieved a viral load < 50 copies/ml at any point during follow-up. Factors associated with final viral load < 50 copies/ml included not being a cigarette smoker, receiving lamivudine in one's final regimen, and having an HIV risk behavior other than male-male sex.
AB - This study describes the effects of a structured, educational/motivational antiretroviral adherence program on virologic and immunologic parameters in HIV-infected patients. Patients were referred because of either self- or provider-identified barriers to adherence. All patients completed 6 to 8 weekly sessions with a nurse or adherence counselor, followed by four quarterly sessions. Sessions included an adherence assessment, individualized patient education, review of adherence strategies, motivational messages, anticipatory planning, and adherence tools. The 58 patients had a mean enrollment CD4 + count of 223 cells/mm3 and mean viral load of 196,454 copies/ml. At the last follow-up, the mean CD4+ count increased to 308 cells/mm3 (p < .001), and mean viral load decreased to 43,309 (p < .001). Thirty (51.7%) patients achieved a viral load < 50 copies/ml at any point during follow-up. Factors associated with final viral load < 50 copies/ml included not being a cigarette smoker, receiving lamivudine in one's final regimen, and having an HIV risk behavior other than male-male sex.
KW - Adherence
KW - Antiretroviral therapy
KW - Cigarette smoking
KW - HIV
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U2 - 10.1177/1055329004269135
DO - 10.1177/1055329004269135
M3 - Article
C2 - 15358926
AN - SCOPUS:5444271628
VL - 15
SP - 60
EP - 67
JO - Journal of the Association of Nurses in AIDS Care
JF - Journal of the Association of Nurses in AIDS Care
SN - 1055-3290
IS - 5
ER -