Predictors of successful closure of patent ductus arteriosus with indomethacin

M. F. Ahamed, P. Verma, S. Lee, M. Vega, D. Wang, Mimi Kim, Mamta Fuloria

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective:To determine whether platelet counts can predict the likelihood of successful closure of patent ductus arteriosus (PDA) with indomethacin.Study Design:This was a retrospective cohort study of infants <32 weeks' gestational age (GA) and birth weight <1500 g with PDA. Clinical characteristics between infants who achieved ductal closure with indomethacin and those who failed were compared. Multivariable logistic regression was used to identify predictors of successful ductal closure.Results:In infants with hemodynamically significant PDA, older GA (odds ratio=1.54; 95% confidence interval: 1.12 to 2.13), male gender (odds ratio=3.02; 95% confidence interval: 1.08 to 8.49) and higher platelet count (odds ratio=1.5; 95% confidence interval: 1.04 to 2.17) prior to indomethacin treatment were associated with successful ductal closure with indomethacin.Conclusion:Older GA, male gender and higher platelet count at time of treatment of hemodynamically significant PDA are predictors of successful ductal closure with indomethacin.

Original languageEnglish (US)
Pages (from-to)729-734
Number of pages6
JournalJournal of Perinatology
Volume35
Issue number9
DOIs
StatePublished - Sep 28 2015

Fingerprint

Patent Ductus Arteriosus
Indomethacin
Platelet Count
Gestational Age
Odds Ratio
Confidence Intervals
Birth Weight
Cohort Studies
Retrospective Studies
Logistic Models
Therapeutics

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Cite this

Predictors of successful closure of patent ductus arteriosus with indomethacin. / Ahamed, M. F.; Verma, P.; Lee, S.; Vega, M.; Wang, D.; Kim, Mimi; Fuloria, Mamta.

In: Journal of Perinatology, Vol. 35, No. 9, 28.09.2015, p. 729-734.

Research output: Contribution to journalArticle

Ahamed, M. F. ; Verma, P. ; Lee, S. ; Vega, M. ; Wang, D. ; Kim, Mimi ; Fuloria, Mamta. / Predictors of successful closure of patent ductus arteriosus with indomethacin. In: Journal of Perinatology. 2015 ; Vol. 35, No. 9. pp. 729-734.
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