TY - JOUR
T1 - Predictors of postprandial triacylglycerol response in children
T2 - The Columbia University Biomarkers Study
AU - Couch, Sarah C.
AU - Isasi, Carmen R.
AU - Karmally, Wahida
AU - Blaner, William S.
AU - Starc, Thomas J.
AU - Kaluski, Dorit
AU - Deckelbaum, Richard J.
AU - Ginsberg, Henry N.
AU - Shea, Steven
AU - Berglund, Lars
PY - 2000
Y1 - 2000
N2 - Background: Predictors of postprandial lipemia have not been explored in children. Objective: Our objective was to determine whether the postprandial triacylglycerol response is associated with low HDL-cholesterol and high fasting triacylglycerol concentrations and family history of early-onset ischemic heart disease (IHD) in children. Design: We administered a standardized fat load (52.5 g fat/m2) to 60 children (mean age: 14.0 y), 20 with and 40 without a family history of early-onset IHD, and to 29 mothers, all recruited from families enrolled in the Columbia University Biomarkers Study. Plasma lipid and retinyl palmitate concentrations were measured in the fasting state and 3, 6, and 8 h after the oral fat load. Results: In children, postprandial lipemia, as indicated by the incremental area under the triacylglycerol response curve, was associated with elevated fasting triacylglycersol concentrations (≥1.13 mmol/L; P < 0.01), with low fasting HDL-cholesterol concentrations (≤0.91 mmol/L; P < 0.01), and with the combination of low HDL-cholesterol and high triacylglycerol concentrations (P < 0.05). Family history of IHD, baseline LDL-cholesterol concentration, and apolipoprotein E genotype were not associated with the postprandial triacylglycerol or retinyl palmitate response. The mothers had fasting triacylglycerol concentrations similar to those of their children but a more prolonged response with higher triacylglycerol concentrations at 6 and 8 h (P < 0.01 and P < 0.05, respectively). Conclusions: In children, a delayed postprandial triacylglycerol response to a fat load is associated with the combination of high fasting triacylglycerol and low HDL-cholesterol concentrations. Predictors of postprandial triacylglycerol concentrations may be similar in children and adults.
AB - Background: Predictors of postprandial lipemia have not been explored in children. Objective: Our objective was to determine whether the postprandial triacylglycerol response is associated with low HDL-cholesterol and high fasting triacylglycerol concentrations and family history of early-onset ischemic heart disease (IHD) in children. Design: We administered a standardized fat load (52.5 g fat/m2) to 60 children (mean age: 14.0 y), 20 with and 40 without a family history of early-onset IHD, and to 29 mothers, all recruited from families enrolled in the Columbia University Biomarkers Study. Plasma lipid and retinyl palmitate concentrations were measured in the fasting state and 3, 6, and 8 h after the oral fat load. Results: In children, postprandial lipemia, as indicated by the incremental area under the triacylglycerol response curve, was associated with elevated fasting triacylglycersol concentrations (≥1.13 mmol/L; P < 0.01), with low fasting HDL-cholesterol concentrations (≤0.91 mmol/L; P < 0.01), and with the combination of low HDL-cholesterol and high triacylglycerol concentrations (P < 0.05). Family history of IHD, baseline LDL-cholesterol concentration, and apolipoprotein E genotype were not associated with the postprandial triacylglycerol or retinyl palmitate response. The mothers had fasting triacylglycerol concentrations similar to those of their children but a more prolonged response with higher triacylglycerol concentrations at 6 and 8 h (P < 0.01 and P < 0.05, respectively). Conclusions: In children, a delayed postprandial triacylglycerol response to a fat load is associated with the combination of high fasting triacylglycerol and low HDL-cholesterol concentrations. Predictors of postprandial triacylglycerol concentrations may be similar in children and adults.
KW - Atherosclerosis
KW - Children
KW - Columbia University Biomarkers Study
KW - Coronary heart disease
KW - HDL cholesterol
KW - Ischemic heart disease
KW - Postprandial period
KW - Risk factors
KW - Triacylglycerol
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U2 - 10.1093/ajcn/72.5.1119
DO - 10.1093/ajcn/72.5.1119
M3 - Article
C2 - 11063438
AN - SCOPUS:0033744758
SN - 0002-9165
VL - 72
SP - 1119
EP - 1127
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 5
ER -