Predictors of hypomania during ventral capsule/ventral striatum deep brain stimulation

Alik S. Widge; Ernesto Licon; Samuel Zorowitz; Andrew Corse; Amanda R. Arulpragasam; Joan A. Camprodon; Cristina Cusin; Emad N. Eskandar; Thilo Deckersbach; Darin D. Dougherty

doi:10.1176/appi.neuropsych.15040089

Predictors of hypomania during ventral capsule/ventral striatum deep brain stimulation

Alik S. Widge, Ernesto Licon, Samuel Zorowitz, Andrew Corse, Amanda R. Arulpragasam, Joan A. Camprodon, Cristina Cusin, Emad N. Eskandar, Thilo Deckersbach, Darin D. Dougherty

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) is a novel therapy for neuropsychiatric disorders. Hypomania is a known complication of VC/VS DBS, but who is at risk is less understood. Factors such as family history, combined with details of DBS programming, might quantify that risk. The authors performed an iterative modeling procedure on a VC/VS DBS patient registry to identify key predictors. Hypomania was less common for men and for patients stimulated on the ventral right contact. It was more common with right monopolar stimulation. These findings may help to establish decision rules to reduce complications of VC/VS DBS.

Original language	English (US)
Pages (from-to)	38-44
Number of pages	7
Journal	Journal of Neuropsychiatry and Clinical Neurosciences
Volume	28
Issue number	1
DOIs	https://doi.org/10.1176/appi.neuropsych.15040089
State	Published - Dec 1 2016
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1176/appi.neuropsych.15040089

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title = "Predictors of hypomania during ventral capsule/ventral striatum deep brain stimulation",

abstract = "Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) is a novel therapy for neuropsychiatric disorders. Hypomania is a known complication of VC/VS DBS, but who is at risk is less understood. Factors such as family history, combined with details of DBS programming, might quantify that risk. The authors performed an iterative modeling procedure on a VC/VS DBS patient registry to identify key predictors. Hypomania was less common for men and for patients stimulated on the ventral right contact. It was more common with right monopolar stimulation. These findings may help to establish decision rules to reduce complications of VC/VS DBS.",

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AU - Widge, Alik S.

AU - Licon, Ernesto

AU - Zorowitz, Samuel

AU - Corse, Andrew

AU - Arulpragasam, Amanda R.

AU - Camprodon, Joan A.

AU - Cusin, Cristina

AU - Eskandar, Emad N.

AU - Deckersbach, Thilo

AU - Dougherty, Darin D.

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) is a novel therapy for neuropsychiatric disorders. Hypomania is a known complication of VC/VS DBS, but who is at risk is less understood. Factors such as family history, combined with details of DBS programming, might quantify that risk. The authors performed an iterative modeling procedure on a VC/VS DBS patient registry to identify key predictors. Hypomania was less common for men and for patients stimulated on the ventral right contact. It was more common with right monopolar stimulation. These findings may help to establish decision rules to reduce complications of VC/VS DBS.

AB - Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) is a novel therapy for neuropsychiatric disorders. Hypomania is a known complication of VC/VS DBS, but who is at risk is less understood. Factors such as family history, combined with details of DBS programming, might quantify that risk. The authors performed an iterative modeling procedure on a VC/VS DBS patient registry to identify key predictors. Hypomania was less common for men and for patients stimulated on the ventral right contact. It was more common with right monopolar stimulation. These findings may help to establish decision rules to reduce complications of VC/VS DBS.

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Predictors of hypomania during ventral capsule/ventral striatum deep brain stimulation

Abstract

ASJC Scopus subject areas

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