Predictors of high defibrillation threshold in the modern era

Edward F. Lin, Darshan Dalal, Alan Cheng, Joseph E. Marine, Saman Nazarian, Sunil Sinha, David D. Spragg, Harikrishna Tandri, Henry Halperin, Hugh Calkins, Ronald D. Berger, Gordon F. Tomaselli, Charles A. Henrikson

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Introduction High defibrillation threshold (DFT) is a clinical problem in 1-8% of implantable cardioverter-defibrillator implants. Some clinicians and investigators question whether the benefits of routine DFT testing outweigh the risks. Identification of the predictors of elevated DFT may allow selective application of DFT testing. However, the clinical characteristics of patients with high DFT in the modern era have not been well-defined. Methods All patients who underwent DFT testing in our institution during an 8-year period were reviewed for this retrospective study. High DFT was defined as less than a 10-J safety margin on initial testing. For each case, the two cases preceding and two cases following by the same implanter were selected as controls. Results Of the 2,138 patients who underwent DFT testing, 48 (2.2%) met criteria for high DFT. Compared to 192 control patients, patients with high DFT were more likely to be younger (P = 0.004), have nonischemic cardiomyopathy (P = 0.036), have a longer QRS interval (P = 0.026), and have a left ventricular ejection fraction (LVEF) ≤ 0.25 (P = 0.013). On multivariate analysis, only younger age (P = 0.016) and LVEF ≤ 0.25 (P = 0.010) remained statistically significant predictors of elevated DFT. Conclusions High DFT was identified in 2.2% of ICD implants in our institution in recent years. Although younger age and depressed LVEF predicts this problem, elevated DFT occurred in patients of all ages and ejection fractions. Elimination of routine DFT testing appears to be premature given the prevalence and unpredictability of elevated DFT.

Original languageEnglish (US)
Pages (from-to)231-237
Number of pages7
JournalPACE - Pacing and Clinical Electrophysiology
Volume36
Issue number2
DOIs
StatePublished - Feb 1 2013
Externally publishedYes

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Stroke Volume
Implantable Defibrillators
Cardiomyopathies
Multivariate Analysis
Retrospective Studies
Research Personnel
Safety

Keywords

  • high defibrillation threshold
  • implantable cardioverter-defibrillator
  • threshold testing

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Lin, E. F., Dalal, D., Cheng, A., Marine, J. E., Nazarian, S., Sinha, S., ... Henrikson, C. A. (2013). Predictors of high defibrillation threshold in the modern era. PACE - Pacing and Clinical Electrophysiology, 36(2), 231-237. https://doi.org/10.1111/pace.12039

Predictors of high defibrillation threshold in the modern era. / Lin, Edward F.; Dalal, Darshan; Cheng, Alan; Marine, Joseph E.; Nazarian, Saman; Sinha, Sunil; Spragg, David D.; Tandri, Harikrishna; Halperin, Henry; Calkins, Hugh; Berger, Ronald D.; Tomaselli, Gordon F.; Henrikson, Charles A.

In: PACE - Pacing and Clinical Electrophysiology, Vol. 36, No. 2, 01.02.2013, p. 231-237.

Research output: Contribution to journalArticle

Lin, EF, Dalal, D, Cheng, A, Marine, JE, Nazarian, S, Sinha, S, Spragg, DD, Tandri, H, Halperin, H, Calkins, H, Berger, RD, Tomaselli, GF & Henrikson, CA 2013, 'Predictors of high defibrillation threshold in the modern era', PACE - Pacing and Clinical Electrophysiology, vol. 36, no. 2, pp. 231-237. https://doi.org/10.1111/pace.12039
Lin EF, Dalal D, Cheng A, Marine JE, Nazarian S, Sinha S et al. Predictors of high defibrillation threshold in the modern era. PACE - Pacing and Clinical Electrophysiology. 2013 Feb 1;36(2):231-237. https://doi.org/10.1111/pace.12039
Lin, Edward F. ; Dalal, Darshan ; Cheng, Alan ; Marine, Joseph E. ; Nazarian, Saman ; Sinha, Sunil ; Spragg, David D. ; Tandri, Harikrishna ; Halperin, Henry ; Calkins, Hugh ; Berger, Ronald D. ; Tomaselli, Gordon F. ; Henrikson, Charles A. / Predictors of high defibrillation threshold in the modern era. In: PACE - Pacing and Clinical Electrophysiology. 2013 ; Vol. 36, No. 2. pp. 231-237.
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abstract = "Introduction High defibrillation threshold (DFT) is a clinical problem in 1-8{\%} of implantable cardioverter-defibrillator implants. Some clinicians and investigators question whether the benefits of routine DFT testing outweigh the risks. Identification of the predictors of elevated DFT may allow selective application of DFT testing. However, the clinical characteristics of patients with high DFT in the modern era have not been well-defined. Methods All patients who underwent DFT testing in our institution during an 8-year period were reviewed for this retrospective study. High DFT was defined as less than a 10-J safety margin on initial testing. For each case, the two cases preceding and two cases following by the same implanter were selected as controls. Results Of the 2,138 patients who underwent DFT testing, 48 (2.2{\%}) met criteria for high DFT. Compared to 192 control patients, patients with high DFT were more likely to be younger (P = 0.004), have nonischemic cardiomyopathy (P = 0.036), have a longer QRS interval (P = 0.026), and have a left ventricular ejection fraction (LVEF) ≤ 0.25 (P = 0.013). On multivariate analysis, only younger age (P = 0.016) and LVEF ≤ 0.25 (P = 0.010) remained statistically significant predictors of elevated DFT. Conclusions High DFT was identified in 2.2{\%} of ICD implants in our institution in recent years. Although younger age and depressed LVEF predicts this problem, elevated DFT occurred in patients of all ages and ejection fractions. Elimination of routine DFT testing appears to be premature given the prevalence and unpredictability of elevated DFT.",
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AU - Spragg, David D.

AU - Tandri, Harikrishna

AU - Halperin, Henry

AU - Calkins, Hugh

AU - Berger, Ronald D.

AU - Tomaselli, Gordon F.

AU - Henrikson, Charles A.

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N2 - Introduction High defibrillation threshold (DFT) is a clinical problem in 1-8% of implantable cardioverter-defibrillator implants. Some clinicians and investigators question whether the benefits of routine DFT testing outweigh the risks. Identification of the predictors of elevated DFT may allow selective application of DFT testing. However, the clinical characteristics of patients with high DFT in the modern era have not been well-defined. Methods All patients who underwent DFT testing in our institution during an 8-year period were reviewed for this retrospective study. High DFT was defined as less than a 10-J safety margin on initial testing. For each case, the two cases preceding and two cases following by the same implanter were selected as controls. Results Of the 2,138 patients who underwent DFT testing, 48 (2.2%) met criteria for high DFT. Compared to 192 control patients, patients with high DFT were more likely to be younger (P = 0.004), have nonischemic cardiomyopathy (P = 0.036), have a longer QRS interval (P = 0.026), and have a left ventricular ejection fraction (LVEF) ≤ 0.25 (P = 0.013). On multivariate analysis, only younger age (P = 0.016) and LVEF ≤ 0.25 (P = 0.010) remained statistically significant predictors of elevated DFT. Conclusions High DFT was identified in 2.2% of ICD implants in our institution in recent years. Although younger age and depressed LVEF predicts this problem, elevated DFT occurred in patients of all ages and ejection fractions. Elimination of routine DFT testing appears to be premature given the prevalence and unpredictability of elevated DFT.

AB - Introduction High defibrillation threshold (DFT) is a clinical problem in 1-8% of implantable cardioverter-defibrillator implants. Some clinicians and investigators question whether the benefits of routine DFT testing outweigh the risks. Identification of the predictors of elevated DFT may allow selective application of DFT testing. However, the clinical characteristics of patients with high DFT in the modern era have not been well-defined. Methods All patients who underwent DFT testing in our institution during an 8-year period were reviewed for this retrospective study. High DFT was defined as less than a 10-J safety margin on initial testing. For each case, the two cases preceding and two cases following by the same implanter were selected as controls. Results Of the 2,138 patients who underwent DFT testing, 48 (2.2%) met criteria for high DFT. Compared to 192 control patients, patients with high DFT were more likely to be younger (P = 0.004), have nonischemic cardiomyopathy (P = 0.036), have a longer QRS interval (P = 0.026), and have a left ventricular ejection fraction (LVEF) ≤ 0.25 (P = 0.013). On multivariate analysis, only younger age (P = 0.016) and LVEF ≤ 0.25 (P = 0.010) remained statistically significant predictors of elevated DFT. Conclusions High DFT was identified in 2.2% of ICD implants in our institution in recent years. Although younger age and depressed LVEF predicts this problem, elevated DFT occurred in patients of all ages and ejection fractions. Elimination of routine DFT testing appears to be premature given the prevalence and unpredictability of elevated DFT.

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