TY - JOUR
T1 - Predictors of candidate maturation among potential living donors
AU - Verna, Elizabeth C.
AU - Hunt, Kristel H.
AU - Renz, John F.
AU - Rudow, Dianne La Pointe
AU - Hafliger, Sylvia
AU - Dove, Lorna M.
AU - Kinkhabwala, Milan
AU - Emond, Jean C.
AU - Brown, Robert S.
PY - 2005/10
Y1 - 2005/10
N2 - The shortage of deceased donor allografts and improved outcomes in partial organ transplantation have led to widespread application of adult-to-adult living donor liver transplantation. Donor selection limits overall utilization of this technique and predictors of candidate maturation have been inadequately studied to date. We therefore collected data on 237 consecutive potential donors including their age, sex, ethnicity, relationship to the recipient, education, employment and religious beliefs and practices. Of these 237 candidates, 91 (38%) were excluded for medical and psychosocial reasons, 53 (22%) withdrew from the process predonation and 93 (39%) underwent partial liver donation. In multivariate analyses, the relationship between the donor and the recipient was highly predictive of successful donation. For pediatric recipients, no parents voluntarily withdrew from the evaluation process. For adult recipients, spouses are the most likely to donate, followed by parents, children and siblings. Additional predictors for donation included self-description as religious but not regularly practicing, part-time employment and higher education. Race, ethnicity, gender and age did not predict donation in multivariate analysis. Further understanding of the complex decision to donate may improve donation rates as well as permit more efficient and cost-effective donor evaluation strategies.
AB - The shortage of deceased donor allografts and improved outcomes in partial organ transplantation have led to widespread application of adult-to-adult living donor liver transplantation. Donor selection limits overall utilization of this technique and predictors of candidate maturation have been inadequately studied to date. We therefore collected data on 237 consecutive potential donors including their age, sex, ethnicity, relationship to the recipient, education, employment and religious beliefs and practices. Of these 237 candidates, 91 (38%) were excluded for medical and psychosocial reasons, 53 (22%) withdrew from the process predonation and 93 (39%) underwent partial liver donation. In multivariate analyses, the relationship between the donor and the recipient was highly predictive of successful donation. For pediatric recipients, no parents voluntarily withdrew from the evaluation process. For adult recipients, spouses are the most likely to donate, followed by parents, children and siblings. Additional predictors for donation included self-description as religious but not regularly practicing, part-time employment and higher education. Race, ethnicity, gender and age did not predict donation in multivariate analysis. Further understanding of the complex decision to donate may improve donation rates as well as permit more efficient and cost-effective donor evaluation strategies.
KW - Demographics
KW - Liver transplant
KW - Living donor
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U2 - 10.1111/j.1600-6143.2005.01066.x
DO - 10.1111/j.1600-6143.2005.01066.x
M3 - Article
C2 - 16162206
AN - SCOPUS:33644673438
SN - 1600-6135
VL - 5
SP - 2549
EP - 2554
JO - American Journal of Transplantation
JF - American Journal of Transplantation
IS - 10
ER -