Predictors of breast cancer development in women with atypical ductal hyperplasia and atypical lobular hyperplasia

Amy Whiffen, Mahmoud El-Tamer, Brett Taback, Sheldon M. Feldman, Kathie Ann Joseph

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Atypical ductal hyperplasia and atypical lobular neoplasia are common benign breast diseases that increase breast cancer risk. We performed a cohort analysis that compared atypia patients for additional risk factors to asses the effect on breast cancer risk by atypia status. Methods: This longitudinal cohort study used data from the Women At Risk High-Risk Registry at Columbia University Medical Center, New York. Women with atypia were compared to women without atypia across known risk factors to determine the combined effect on breast cancer development. Odds ratios (ORs) stratified by atypia status were calculated for each risk factor of interest with 95% confidence intervals (95% CIs). P values were calculated to determine statistical significance. Results: The study population included 1598 high-risk women, 921 (57.6%) of whom had a history of biopsy-proven atypia. The remaining 677 high-risk women (42.4%) did not have atypia. Fifty women (3.1%) developed breast cancer. Alcohol was significantly associated with the development of breast cancer (P = 0.02) and increased breast cancer risk among women with atypia (OR, 2.13; 95% CI, 0.95-4.81) compared to women without atypia (OR, 1.71). The odds of breast cancer were higher for atypia patients with first-degree relatives (OR, 1.48; 95% CI, 0.64-3.35) compared to women with a relative and no atypia diagnosis (OR, 0.98; 95% CI, 0.41-2.63). The other risk factors of interest did not differ significantly by atypia status. Conclusions: Atypia patients who drank alcohol and had a first-degree relative with breast cancer have an increased risk of breast cancer compared to those without atypia. Continued understanding of the high-risk population will lead to more individualized protocols for risk reduction and prevention.

Original languageEnglish (US)
Pages (from-to)463-467
Number of pages5
JournalAnnals of Surgical Oncology
Volume18
Issue number2
DOIs
StatePublished - Feb 1 2011
Externally publishedYes

Fingerprint

Carcinoma, Intraductal, Noninfiltrating
Hyperplasia
Breast Neoplasms
Odds Ratio
Confidence Intervals
Cohort Studies
Alcohols
Breast Diseases
Equidae
Risk Reduction Behavior
Population
Longitudinal Studies
Registries
Biopsy

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Predictors of breast cancer development in women with atypical ductal hyperplasia and atypical lobular hyperplasia. / Whiffen, Amy; El-Tamer, Mahmoud; Taback, Brett; Feldman, Sheldon M.; Joseph, Kathie Ann.

In: Annals of Surgical Oncology, Vol. 18, No. 2, 01.02.2011, p. 463-467.

Research output: Contribution to journalArticle

Whiffen, Amy ; El-Tamer, Mahmoud ; Taback, Brett ; Feldman, Sheldon M. ; Joseph, Kathie Ann. / Predictors of breast cancer development in women with atypical ductal hyperplasia and atypical lobular hyperplasia. In: Annals of Surgical Oncology. 2011 ; Vol. 18, No. 2. pp. 463-467.
@article{404b0dad19384772b33d1467d78d7f97,
title = "Predictors of breast cancer development in women with atypical ductal hyperplasia and atypical lobular hyperplasia",
abstract = "Background: Atypical ductal hyperplasia and atypical lobular neoplasia are common benign breast diseases that increase breast cancer risk. We performed a cohort analysis that compared atypia patients for additional risk factors to asses the effect on breast cancer risk by atypia status. Methods: This longitudinal cohort study used data from the Women At Risk High-Risk Registry at Columbia University Medical Center, New York. Women with atypia were compared to women without atypia across known risk factors to determine the combined effect on breast cancer development. Odds ratios (ORs) stratified by atypia status were calculated for each risk factor of interest with 95{\%} confidence intervals (95{\%} CIs). P values were calculated to determine statistical significance. Results: The study population included 1598 high-risk women, 921 (57.6{\%}) of whom had a history of biopsy-proven atypia. The remaining 677 high-risk women (42.4{\%}) did not have atypia. Fifty women (3.1{\%}) developed breast cancer. Alcohol was significantly associated with the development of breast cancer (P = 0.02) and increased breast cancer risk among women with atypia (OR, 2.13; 95{\%} CI, 0.95-4.81) compared to women without atypia (OR, 1.71). The odds of breast cancer were higher for atypia patients with first-degree relatives (OR, 1.48; 95{\%} CI, 0.64-3.35) compared to women with a relative and no atypia diagnosis (OR, 0.98; 95{\%} CI, 0.41-2.63). The other risk factors of interest did not differ significantly by atypia status. Conclusions: Atypia patients who drank alcohol and had a first-degree relative with breast cancer have an increased risk of breast cancer compared to those without atypia. Continued understanding of the high-risk population will lead to more individualized protocols for risk reduction and prevention.",
author = "Amy Whiffen and Mahmoud El-Tamer and Brett Taback and Feldman, {Sheldon M.} and Joseph, {Kathie Ann}",
year = "2011",
month = "2",
day = "1",
doi = "10.1245/s10434-010-1340-5",
language = "English (US)",
volume = "18",
pages = "463--467",
journal = "Annals of Surgical Oncology",
issn = "1068-9265",
publisher = "Springer New York",
number = "2",

}

TY - JOUR

T1 - Predictors of breast cancer development in women with atypical ductal hyperplasia and atypical lobular hyperplasia

AU - Whiffen, Amy

AU - El-Tamer, Mahmoud

AU - Taback, Brett

AU - Feldman, Sheldon M.

AU - Joseph, Kathie Ann

PY - 2011/2/1

Y1 - 2011/2/1

N2 - Background: Atypical ductal hyperplasia and atypical lobular neoplasia are common benign breast diseases that increase breast cancer risk. We performed a cohort analysis that compared atypia patients for additional risk factors to asses the effect on breast cancer risk by atypia status. Methods: This longitudinal cohort study used data from the Women At Risk High-Risk Registry at Columbia University Medical Center, New York. Women with atypia were compared to women without atypia across known risk factors to determine the combined effect on breast cancer development. Odds ratios (ORs) stratified by atypia status were calculated for each risk factor of interest with 95% confidence intervals (95% CIs). P values were calculated to determine statistical significance. Results: The study population included 1598 high-risk women, 921 (57.6%) of whom had a history of biopsy-proven atypia. The remaining 677 high-risk women (42.4%) did not have atypia. Fifty women (3.1%) developed breast cancer. Alcohol was significantly associated with the development of breast cancer (P = 0.02) and increased breast cancer risk among women with atypia (OR, 2.13; 95% CI, 0.95-4.81) compared to women without atypia (OR, 1.71). The odds of breast cancer were higher for atypia patients with first-degree relatives (OR, 1.48; 95% CI, 0.64-3.35) compared to women with a relative and no atypia diagnosis (OR, 0.98; 95% CI, 0.41-2.63). The other risk factors of interest did not differ significantly by atypia status. Conclusions: Atypia patients who drank alcohol and had a first-degree relative with breast cancer have an increased risk of breast cancer compared to those without atypia. Continued understanding of the high-risk population will lead to more individualized protocols for risk reduction and prevention.

AB - Background: Atypical ductal hyperplasia and atypical lobular neoplasia are common benign breast diseases that increase breast cancer risk. We performed a cohort analysis that compared atypia patients for additional risk factors to asses the effect on breast cancer risk by atypia status. Methods: This longitudinal cohort study used data from the Women At Risk High-Risk Registry at Columbia University Medical Center, New York. Women with atypia were compared to women without atypia across known risk factors to determine the combined effect on breast cancer development. Odds ratios (ORs) stratified by atypia status were calculated for each risk factor of interest with 95% confidence intervals (95% CIs). P values were calculated to determine statistical significance. Results: The study population included 1598 high-risk women, 921 (57.6%) of whom had a history of biopsy-proven atypia. The remaining 677 high-risk women (42.4%) did not have atypia. Fifty women (3.1%) developed breast cancer. Alcohol was significantly associated with the development of breast cancer (P = 0.02) and increased breast cancer risk among women with atypia (OR, 2.13; 95% CI, 0.95-4.81) compared to women without atypia (OR, 1.71). The odds of breast cancer were higher for atypia patients with first-degree relatives (OR, 1.48; 95% CI, 0.64-3.35) compared to women with a relative and no atypia diagnosis (OR, 0.98; 95% CI, 0.41-2.63). The other risk factors of interest did not differ significantly by atypia status. Conclusions: Atypia patients who drank alcohol and had a first-degree relative with breast cancer have an increased risk of breast cancer compared to those without atypia. Continued understanding of the high-risk population will lead to more individualized protocols for risk reduction and prevention.

UR - http://www.scopus.com/inward/record.url?scp=79951550730&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79951550730&partnerID=8YFLogxK

U2 - 10.1245/s10434-010-1340-5

DO - 10.1245/s10434-010-1340-5

M3 - Article

C2 - 20878246

AN - SCOPUS:79951550730

VL - 18

SP - 463

EP - 467

JO - Annals of Surgical Oncology

JF - Annals of Surgical Oncology

SN - 1068-9265

IS - 2

ER -