Predictive value of CD8+ T lymphocytes for CMV retinitis in patients with CD4+ cells < 50

Umar K. Mian, G. Etwaru, M. Mayers

Research output: Contribution to journalArticle

Abstract

Purpose. To substantiate whether CD8+ has a predictive value for CMV retinitis (CMVR) in patients with CD4+ less than 50. Method. 55 AIDS patients with CD4+<50 and complete records, seen for routine examination, at the Bronx Lebanon eye clinic between June 94 and February 1995, were included. Patients without a history of CMVR and T-Cell count within three months of examination were included. A dilated fundus examination with an indirect ophthalmoscope and a 2.2D lens was performed on each patient. Results. 55 patients were included in the study. There were 16 females and 39 males with an average age of 37.2 years. The Black : Hispanic : White ratio was 6.7:4.7:1. 10 out of the 55 patients had CMVR (18.2%). The Mean CD4+ was 14.9 and CD8+ was 323.7 for all patients. The mean CD4+ for patients with CMVR was 6.6 and without CMV was 16.7. This difference was statistically significant (P <0.05). The mean CD8+ for patients with CMVR was 323.7, and without CMVR was 343.5. This difference was not statistically significant. The mean CD4+/CD8+ ratio for patients with and without CMVR was 0.035 and 0.067, respectively. This difference was also not statistically significant. Conclusions. We have previously shown that patients with CD4+ of < 50 are at a higher risk of CMVR and as the count decreases the risk of retinitis increases. In our series we found the absolute CD8+ count or the CD4+/CD8+ ratio not to be helpful in predicting CMVR in patients with CD4+ of < 50.

Original languageEnglish (US)
JournalInvestigative Ophthalmology and Visual Science
Volume37
Issue number3
StatePublished - Feb 15 1996

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Retinitis
T-Lymphocytes
CD4-CD8 Ratio
Ophthalmoscopes
Lebanon
Hispanic Americans
Lenses
Acquired Immunodeficiency Syndrome

ASJC Scopus subject areas

  • Ophthalmology

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Predictive value of CD8+ T lymphocytes for CMV retinitis in patients with CD4+ cells < 50. / Mian, Umar K.; Etwaru, G.; Mayers, M.

In: Investigative Ophthalmology and Visual Science, Vol. 37, No. 3, 15.02.1996.

Research output: Contribution to journalArticle

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abstract = "Purpose. To substantiate whether CD8+ has a predictive value for CMV retinitis (CMVR) in patients with CD4+ less than 50. Method. 55 AIDS patients with CD4+<50 and complete records, seen for routine examination, at the Bronx Lebanon eye clinic between June 94 and February 1995, were included. Patients without a history of CMVR and T-Cell count within three months of examination were included. A dilated fundus examination with an indirect ophthalmoscope and a 2.2D lens was performed on each patient. Results. 55 patients were included in the study. There were 16 females and 39 males with an average age of 37.2 years. The Black : Hispanic : White ratio was 6.7:4.7:1. 10 out of the 55 patients had CMVR (18.2{\%}). The Mean CD4+ was 14.9 and CD8+ was 323.7 for all patients. The mean CD4+ for patients with CMVR was 6.6 and without CMV was 16.7. This difference was statistically significant (P <0.05). The mean CD8+ for patients with CMVR was 323.7, and without CMVR was 343.5. This difference was not statistically significant. The mean CD4+/CD8+ ratio for patients with and without CMVR was 0.035 and 0.067, respectively. This difference was also not statistically significant. Conclusions. We have previously shown that patients with CD4+ of < 50 are at a higher risk of CMVR and as the count decreases the risk of retinitis increases. In our series we found the absolute CD8+ count or the CD4+/CD8+ ratio not to be helpful in predicting CMVR in patients with CD4+ of < 50.",
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N2 - Purpose. To substantiate whether CD8+ has a predictive value for CMV retinitis (CMVR) in patients with CD4+ less than 50. Method. 55 AIDS patients with CD4+<50 and complete records, seen for routine examination, at the Bronx Lebanon eye clinic between June 94 and February 1995, were included. Patients without a history of CMVR and T-Cell count within three months of examination were included. A dilated fundus examination with an indirect ophthalmoscope and a 2.2D lens was performed on each patient. Results. 55 patients were included in the study. There were 16 females and 39 males with an average age of 37.2 years. The Black : Hispanic : White ratio was 6.7:4.7:1. 10 out of the 55 patients had CMVR (18.2%). The Mean CD4+ was 14.9 and CD8+ was 323.7 for all patients. The mean CD4+ for patients with CMVR was 6.6 and without CMV was 16.7. This difference was statistically significant (P <0.05). The mean CD8+ for patients with CMVR was 323.7, and without CMVR was 343.5. This difference was not statistically significant. The mean CD4+/CD8+ ratio for patients with and without CMVR was 0.035 and 0.067, respectively. This difference was also not statistically significant. Conclusions. We have previously shown that patients with CD4+ of < 50 are at a higher risk of CMVR and as the count decreases the risk of retinitis increases. In our series we found the absolute CD8+ count or the CD4+/CD8+ ratio not to be helpful in predicting CMVR in patients with CD4+ of < 50.

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