Prediagnostic blood levels of organochlorines and risk of non-Hodgkin lymphoma in three prospective cohorts in China and Singapore

Bryan A. Bassig, Xiao Ou Shu, Andreas Sjödin, Woon Puay Koh, Yu Tang Gao, Jennifer Adams-Haduch, Mark Davis, Renwei Wang, Yong Bing Xiang, Lawrence S. Engel, Mark P. Purdue, Bu Tian Ji, Gong Yang, Richard S. Jones, Hilde Langseth, Howard D. Hosgood, Tom K. Grimsrud, Wei Jie Seow, Jason Y.Y. Wong, Wei HuDazhe Chen, Wei Zheng, Jian Min Yuan, Qing Lan, Nathaniel Rothman

Research output: Contribution to journalArticle

Abstract

Specific organochlorines (OCs) have been associated with non-Hodgkin lymphoma (NHL) with varying degrees of evidence. These associations have not been evaluated in Asia, where the high exposure and historical environmental contamination of certain OC pesticides (e.g., dichlorodiphenyltrichloroethane [DDT], hexachlorocyclohexane [HCH]) are different from Western populations. We evaluated NHL risk and prediagnostic blood levels of OC pesticides/metabolites and polychlorinated biphenyl congeners in a case–control study of 167 NHL cases and 167 controls nested within three prospective cohorts in Shanghai and Singapore. Conditional logistic regression was used to analyze lipid-adjusted OC levels and NHL risk. Median levels of p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE), the primary DDT metabolite, and β-HCH were up to 12 and 65 times higher, respectively, in samples from the Asian cohorts compared to several cohorts in the United States and Norway. An increased risk of NHL was observed among those with higher β-HCH levels both overall (3rd vs. 1st tertile OR = 1.8, 95%CI = 1.0–3.2; p trend = 0.049) and after excluding cases diagnosed within 2 years of blood collection (3rd vs. 1st tertile OR = 2.0, 95%CI = 1.1–3.9; p trend = 0.03), and the association was highly consistent across the three cohorts. No significant associations were observed for other OCs, including p,p′-DDE. Our findings provide support for an association between β-HCH blood levels and NHL risk. This is a concern because substantial quantities of persistent, toxic residues of HCH are present in the environment worldwide. Although there is some evidence that DDT is associated with NHL, our findings for p,p′-DDE do not support an association.

Original languageEnglish (US)
JournalInternational Journal of Cancer
DOIs
StatePublished - Jan 1 2019

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Singapore
Non-Hodgkin's Lymphoma
Lindane
China
Dichlorodiphenyl Dichloroethylene
Pesticides
Poisons
Polychlorinated Biphenyls
Environmental Exposure
Norway
Logistic Models
Lipids
Population

Keywords

  • Chinese cohort
  • DDT
  • hexachlorocyclohexane
  • non-Hodgkin lymphoma
  • organochlorines

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Prediagnostic blood levels of organochlorines and risk of non-Hodgkin lymphoma in three prospective cohorts in China and Singapore. / Bassig, Bryan A.; Shu, Xiao Ou; Sjödin, Andreas; Koh, Woon Puay; Gao, Yu Tang; Adams-Haduch, Jennifer; Davis, Mark; Wang, Renwei; Xiang, Yong Bing; Engel, Lawrence S.; Purdue, Mark P.; Ji, Bu Tian; Yang, Gong; Jones, Richard S.; Langseth, Hilde; Hosgood, Howard D.; Grimsrud, Tom K.; Seow, Wei Jie; Wong, Jason Y.Y.; Hu, Wei; Chen, Dazhe; Zheng, Wei; Yuan, Jian Min; Lan, Qing; Rothman, Nathaniel.

In: International Journal of Cancer, 01.01.2019.

Research output: Contribution to journalArticle

Bassig, BA, Shu, XO, Sjödin, A, Koh, WP, Gao, YT, Adams-Haduch, J, Davis, M, Wang, R, Xiang, YB, Engel, LS, Purdue, MP, Ji, BT, Yang, G, Jones, RS, Langseth, H, Hosgood, HD, Grimsrud, TK, Seow, WJ, Wong, JYY, Hu, W, Chen, D, Zheng, W, Yuan, JM, Lan, Q & Rothman, N 2019, 'Prediagnostic blood levels of organochlorines and risk of non-Hodgkin lymphoma in three prospective cohorts in China and Singapore', International Journal of Cancer. https://doi.org/10.1002/ijc.32350
Bassig, Bryan A. ; Shu, Xiao Ou ; Sjödin, Andreas ; Koh, Woon Puay ; Gao, Yu Tang ; Adams-Haduch, Jennifer ; Davis, Mark ; Wang, Renwei ; Xiang, Yong Bing ; Engel, Lawrence S. ; Purdue, Mark P. ; Ji, Bu Tian ; Yang, Gong ; Jones, Richard S. ; Langseth, Hilde ; Hosgood, Howard D. ; Grimsrud, Tom K. ; Seow, Wei Jie ; Wong, Jason Y.Y. ; Hu, Wei ; Chen, Dazhe ; Zheng, Wei ; Yuan, Jian Min ; Lan, Qing ; Rothman, Nathaniel. / Prediagnostic blood levels of organochlorines and risk of non-Hodgkin lymphoma in three prospective cohorts in China and Singapore. In: International Journal of Cancer. 2019.
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abstract = "Specific organochlorines (OCs) have been associated with non-Hodgkin lymphoma (NHL) with varying degrees of evidence. These associations have not been evaluated in Asia, where the high exposure and historical environmental contamination of certain OC pesticides (e.g., dichlorodiphenyltrichloroethane [DDT], hexachlorocyclohexane [HCH]) are different from Western populations. We evaluated NHL risk and prediagnostic blood levels of OC pesticides/metabolites and polychlorinated biphenyl congeners in a case–control study of 167 NHL cases and 167 controls nested within three prospective cohorts in Shanghai and Singapore. Conditional logistic regression was used to analyze lipid-adjusted OC levels and NHL risk. Median levels of p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE), the primary DDT metabolite, and β-HCH were up to 12 and 65 times higher, respectively, in samples from the Asian cohorts compared to several cohorts in the United States and Norway. An increased risk of NHL was observed among those with higher β-HCH levels both overall (3rd vs. 1st tertile OR = 1.8, 95{\%}CI = 1.0–3.2; p trend = 0.049) and after excluding cases diagnosed within 2 years of blood collection (3rd vs. 1st tertile OR = 2.0, 95{\%}CI = 1.1–3.9; p trend = 0.03), and the association was highly consistent across the three cohorts. No significant associations were observed for other OCs, including p,p′-DDE. Our findings provide support for an association between β-HCH blood levels and NHL risk. This is a concern because substantial quantities of persistent, toxic residues of HCH are present in the environment worldwide. Although there is some evidence that DDT is associated with NHL, our findings for p,p′-DDE do not support an association.",
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AU - Davis, Mark

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AU - Hosgood, Howard D.

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AU - Seow, Wei Jie

AU - Wong, Jason Y.Y.

AU - Hu, Wei

AU - Chen, Dazhe

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AU - Yuan, Jian Min

AU - Lan, Qing

AU - Rothman, Nathaniel

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