Abstract
Specific organochlorines (OCs) have been associated with non-Hodgkin lymphoma (NHL) with varying degrees of evidence. These associations have not been evaluated in Asia, where the high exposure and historical environmental contamination of certain OC pesticides (e.g., dichlorodiphenyltrichloroethane [DDT], hexachlorocyclohexane [HCH]) are different from Western populations. We evaluated NHL risk and prediagnostic blood levels of OC pesticides/metabolites and polychlorinated biphenyl congeners in a case–control study of 167 NHL cases and 167 controls nested within three prospective cohorts in Shanghai and Singapore. Conditional logistic regression was used to analyze lipid-adjusted OC levels and NHL risk. Median levels of p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE), the primary DDT metabolite, and β-HCH were up to 12 and 65 times higher, respectively, in samples from the Asian cohorts compared to several cohorts in the United States and Norway. An increased risk of NHL was observed among those with higher β-HCH levels both overall (3rd vs. 1st tertile OR = 1.8, 95%CI = 1.0–3.2; p trend = 0.049) and after excluding cases diagnosed within 2 years of blood collection (3rd vs. 1st tertile OR = 2.0, 95%CI = 1.1–3.9; p trend = 0.03), and the association was highly consistent across the three cohorts. No significant associations were observed for other OCs, including p,p′-DDE. Our findings provide support for an association between β-HCH blood levels and NHL risk. This is a concern because substantial quantities of persistent, toxic residues of HCH are present in the environment worldwide. Although there is some evidence that DDT is associated with NHL, our findings for p,p′-DDE do not support an association.
| Original language | English (US) |
|---|---|
| Journal | International Journal of Cancer |
| DOIs | |
| State | Published - Jan 1 2019 |
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Keywords
- Chinese cohort
- DDT
- hexachlorocyclohexane
- non-Hodgkin lymphoma
- organochlorines
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Prediagnostic blood levels of organochlorines and risk of non-Hodgkin lymphoma in three prospective cohorts in China and Singapore. / Bassig, Bryan A.; Shu, Xiao Ou; Sjödin, Andreas; Koh, Woon Puay; Gao, Yu Tang; Adams-Haduch, Jennifer; Davis, Mark; Wang, Renwei; Xiang, Yong Bing; Engel, Lawrence S.; Purdue, Mark P.; Ji, Bu Tian; Yang, Gong; Jones, Richard S.; Langseth, Hilde; Hosgood, Howard D.; Grimsrud, Tom K.; Seow, Wei Jie; Wong, Jason Y.Y.; Hu, Wei; Chen, Dazhe; Zheng, Wei; Yuan, Jian Min; Lan, Qing; Rothman, Nathaniel.
In: International Journal of Cancer, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prediagnostic blood levels of organochlorines and risk of non-Hodgkin lymphoma in three prospective cohorts in China and Singapore
AU - Bassig, Bryan A.
AU - Shu, Xiao Ou
AU - Sjödin, Andreas
AU - Koh, Woon Puay
AU - Gao, Yu Tang
AU - Adams-Haduch, Jennifer
AU - Davis, Mark
AU - Wang, Renwei
AU - Xiang, Yong Bing
AU - Engel, Lawrence S.
AU - Purdue, Mark P.
AU - Ji, Bu Tian
AU - Yang, Gong
AU - Jones, Richard S.
AU - Langseth, Hilde
AU - Hosgood, Howard D.
AU - Grimsrud, Tom K.
AU - Seow, Wei Jie
AU - Wong, Jason Y.Y.
AU - Hu, Wei
AU - Chen, Dazhe
AU - Zheng, Wei
AU - Yuan, Jian Min
AU - Lan, Qing
AU - Rothman, Nathaniel
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Specific organochlorines (OCs) have been associated with non-Hodgkin lymphoma (NHL) with varying degrees of evidence. These associations have not been evaluated in Asia, where the high exposure and historical environmental contamination of certain OC pesticides (e.g., dichlorodiphenyltrichloroethane [DDT], hexachlorocyclohexane [HCH]) are different from Western populations. We evaluated NHL risk and prediagnostic blood levels of OC pesticides/metabolites and polychlorinated biphenyl congeners in a case–control study of 167 NHL cases and 167 controls nested within three prospective cohorts in Shanghai and Singapore. Conditional logistic regression was used to analyze lipid-adjusted OC levels and NHL risk. Median levels of p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE), the primary DDT metabolite, and β-HCH were up to 12 and 65 times higher, respectively, in samples from the Asian cohorts compared to several cohorts in the United States and Norway. An increased risk of NHL was observed among those with higher β-HCH levels both overall (3rd vs. 1st tertile OR = 1.8, 95%CI = 1.0–3.2; p trend = 0.049) and after excluding cases diagnosed within 2 years of blood collection (3rd vs. 1st tertile OR = 2.0, 95%CI = 1.1–3.9; p trend = 0.03), and the association was highly consistent across the three cohorts. No significant associations were observed for other OCs, including p,p′-DDE. Our findings provide support for an association between β-HCH blood levels and NHL risk. This is a concern because substantial quantities of persistent, toxic residues of HCH are present in the environment worldwide. Although there is some evidence that DDT is associated with NHL, our findings for p,p′-DDE do not support an association.
AB - Specific organochlorines (OCs) have been associated with non-Hodgkin lymphoma (NHL) with varying degrees of evidence. These associations have not been evaluated in Asia, where the high exposure and historical environmental contamination of certain OC pesticides (e.g., dichlorodiphenyltrichloroethane [DDT], hexachlorocyclohexane [HCH]) are different from Western populations. We evaluated NHL risk and prediagnostic blood levels of OC pesticides/metabolites and polychlorinated biphenyl congeners in a case–control study of 167 NHL cases and 167 controls nested within three prospective cohorts in Shanghai and Singapore. Conditional logistic regression was used to analyze lipid-adjusted OC levels and NHL risk. Median levels of p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE), the primary DDT metabolite, and β-HCH were up to 12 and 65 times higher, respectively, in samples from the Asian cohorts compared to several cohorts in the United States and Norway. An increased risk of NHL was observed among those with higher β-HCH levels both overall (3rd vs. 1st tertile OR = 1.8, 95%CI = 1.0–3.2; p trend = 0.049) and after excluding cases diagnosed within 2 years of blood collection (3rd vs. 1st tertile OR = 2.0, 95%CI = 1.1–3.9; p trend = 0.03), and the association was highly consistent across the three cohorts. No significant associations were observed for other OCs, including p,p′-DDE. Our findings provide support for an association between β-HCH blood levels and NHL risk. This is a concern because substantial quantities of persistent, toxic residues of HCH are present in the environment worldwide. Although there is some evidence that DDT is associated with NHL, our findings for p,p′-DDE do not support an association.
KW - Chinese cohort
KW - DDT
KW - hexachlorocyclohexane
KW - non-Hodgkin lymphoma
KW - organochlorines
UR - http://www.scopus.com/inward/record.url?scp=85065636240&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065636240&partnerID=8YFLogxK
U2 - 10.1002/ijc.32350
DO - 10.1002/ijc.32350
M3 - Article
C2 - 31001807
AN - SCOPUS:85065636240
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
ER -