@article{4a7896f558ed4aab8c35afdc21835369,
title = "Prediagnostic blood levels of organochlorines and risk of non-Hodgkin lymphoma in three prospective cohorts in China and Singapore",
abstract = "Specific organochlorines (OCs) have been associated with non-Hodgkin lymphoma (NHL) with varying degrees of evidence. These associations have not been evaluated in Asia, where the high exposure and historical environmental contamination of certain OC pesticides (e.g., dichlorodiphenyltrichloroethane [DDT], hexachlorocyclohexane [HCH]) are different from Western populations. We evaluated NHL risk and prediagnostic blood levels of OC pesticides/metabolites and polychlorinated biphenyl congeners in a case–control study of 167 NHL cases and 167 controls nested within three prospective cohorts in Shanghai and Singapore. Conditional logistic regression was used to analyze lipid-adjusted OC levels and NHL risk. Median levels of p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE), the primary DDT metabolite, and β-HCH were up to 12 and 65 times higher, respectively, in samples from the Asian cohorts compared to several cohorts in the United States and Norway. An increased risk of NHL was observed among those with higher β-HCH levels both overall (3rd vs. 1st tertile OR = 1.8, 95%CI = 1.0–3.2; ptrend = 0.049) and after excluding cases diagnosed within 2 years of blood collection (3rd vs. 1st tertile OR = 2.0, 95%CI = 1.1–3.9; ptrend = 0.03), and the association was highly consistent across the three cohorts. No significant associations were observed for other OCs, including p,p′-DDE. Our findings provide support for an association between β-HCH blood levels and NHL risk. This is a concern because substantial quantities of persistent, toxic residues of HCH are present in the environment worldwide. Although there is some evidence that DDT is associated with NHL, our findings for p,p′-DDE do not support an association.",
keywords = "Chinese cohort, DDT, hexachlorocyclohexane, non-Hodgkin lymphoma, organochlorines",
author = "Bassig, {Bryan A.} and Shu, {Xiao Ou} and Andreas Sj{\"o}din and Koh, {Woon Puay} and Gao, {Yu Tang} and Jennifer Adams-Haduch and Mark Davis and Renwei Wang and Xiang, {Yong Bing} and Engel, {Lawrence S.} and Purdue, {Mark P.} and Ji, {Bu Tian} and Gong Yang and Jones, {Richard S.} and Hilde Langseth and Hosgood, {H. Dean} and Grimsrud, {Tom K.} and Seow, {Wei Jie} and Wong, {Jason Y.Y.} and Wei Hu and Dazhe Chen and Wei Zheng and Yuan, {Jian Min} and Qing Lan and Nathaniel Rothman",
note = "Funding Information: This nested case–control study of organochlorines was supported by the Intramural Research Program of the National Institutes of Health, National Cancer Institute and by the U.S. Centers for Disease Control and Prevention (CDC). The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the CDC. Use of trade names is for identification only and does not imply endorsement by the CDC, the Public Health Service or the U.S. Department of Health and Human Services. The Shanghai Cohort Study and the Singapore Chinese Health Study were supported by the U.S. National Institutes of Health grant numbers R01CA144034 and UM1CA182876. The Shanghai Women{\textquoteright}s Health Study was supported by the U.S. National Institutes of Health research grants R37CA70867 and UM1CA173640, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute. Funding Information: This nested case?control study of organochlorines was supported by the Intramural Research Program of the National Institutes of Health, National Cancer Institute and by the U.S. Centers for Disease Control and Prevention (CDC). The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the CDC. Use of trade names is for identification only and does not imply endorsement by the CDC, the Public Health Service or the U.S. Department of Health and Human Services. The Shanghai Cohort Study and the Singapore Chinese Health Study were supported by the U.S. National Institutes of Health grant numbers R01CA144034 and UM1CA182876. The Shanghai Women's Health Study was supported by the U.S. National Institutes of Health research grants R37CA70867 and UM1CA173640, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute. Publisher Copyright: {\textcopyright} 2019 UICC",
year = "2020",
month = feb,
day = "1",
doi = "10.1002/ijc.32350",
language = "English (US)",
volume = "146",
pages = "839--849",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "3",
}
