Precautions in the use of intensity-modulated radiation therapy

James S. Welsh, Jeffery P. Limmer, Steven P. Howard, David Diamond, Paul M. Harari, Wolfgang A. Tome

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Intensity-modulated radiation therapy (IMRT) represents a significant technological advancement in the ability to deliver highly conformal radiation therapy. Thanks to increased availability, general clinical implementation has become progressively more common. However, there are several precautions worthy of comment regarding the clinical applications of IMRT. In theory, the increased irradiated volume and leakage radiation that occasionally accompanies IMRT could contribute to unanticipated complications and safety concerns. The protracted delivery time of IMRT with the associated increased linac monitor units can result in photoactivation of elements within the linac collimator, thereby inadvertently increasing radiation exposure to patients and staff when high-energy photons are used. The increased volumes of normal tissue exposed to lower doses of radiation through IMRT theoretically could promote carcinogenesis and complications due to the bystander effect, low-dose hyperradiosensitivity, and diminished repair of double strand DNA breaks at very low doses. Tumor control may be adversely affected by the lower radiation dose-rates of delivery sometimes associated with IMRT as well the occasionally seen low dose "cold shoulder" on the dose-volume histograms. Unusual clinical reactions can appear as a result of the complex, unfamiliar dose-distributions occasionally generated by IMRT treatment planning. Here we discuss some of the precautions worthy of consideration when using IMRT and how these might be addressed in routine practice.

Original languageEnglish (US)
Pages (from-to)203-210
Number of pages8
JournalTechnology in Cancer Research and Treatment
Volume4
Issue number2
StatePublished - Apr 2005
Externally publishedYes

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Radiotherapy
Radiation
Bystander Effect
Double-Stranded DNA Breaks
Photons
Carcinogenesis
Safety
Neoplasms

Keywords

  • Bystander effect
  • IMRT
  • Low-dose hypersensitivity
  • Radiation dose-rate

ASJC Scopus subject areas

  • Cancer Research
  • Radiology Nuclear Medicine and imaging

Cite this

Welsh, J. S., Limmer, J. P., Howard, S. P., Diamond, D., Harari, P. M., & Tome, W. A. (2005). Precautions in the use of intensity-modulated radiation therapy. Technology in Cancer Research and Treatment, 4(2), 203-210.

Precautions in the use of intensity-modulated radiation therapy. / Welsh, James S.; Limmer, Jeffery P.; Howard, Steven P.; Diamond, David; Harari, Paul M.; Tome, Wolfgang A.

In: Technology in Cancer Research and Treatment, Vol. 4, No. 2, 04.2005, p. 203-210.

Research output: Contribution to journalArticle

Welsh, JS, Limmer, JP, Howard, SP, Diamond, D, Harari, PM & Tome, WA 2005, 'Precautions in the use of intensity-modulated radiation therapy', Technology in Cancer Research and Treatment, vol. 4, no. 2, pp. 203-210.
Welsh JS, Limmer JP, Howard SP, Diamond D, Harari PM, Tome WA. Precautions in the use of intensity-modulated radiation therapy. Technology in Cancer Research and Treatment. 2005 Apr;4(2):203-210.
Welsh, James S. ; Limmer, Jeffery P. ; Howard, Steven P. ; Diamond, David ; Harari, Paul M. ; Tome, Wolfgang A. / Precautions in the use of intensity-modulated radiation therapy. In: Technology in Cancer Research and Treatment. 2005 ; Vol. 4, No. 2. pp. 203-210.
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