Pre- and postweaning food restrictions interact to determine reproductive success and milk volume in rats

M. K. McGuire, Andrea W. Littleton, K. J. Schulze, K. M. Rasmussen

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

This study was designed to determine if nutrient availability during gestation and early life modifies the effects of subsequent dietary intake on reproductive and lactation performance. Rat pups, whose mothers had been allowed free access to food or were food-restricted to 50% of ad libitum consumption were assigned to free access or food restricted groups after weaning, creating 4 groups (pre- and postweaning diet). Pre- and postweaning diets interacted significantly to influence age at conception, number of pups born, and milk yield on d 14 of lactation. Early undernutrition deterred conception in dams later allowed free access to food and resulted in fewer pups born to dams later allowed free access to food, but not those in the food-restricted group. By d 15 of lactation, only dietary treatment after weaning influenced litter weight. Milk yield per gram dam weight was not impaired in the food restricted-ad libitum group but was lowered in dams in the ad libitum-food restricted group. Milk yield per gram litter weight was not impaired in ad libitum-food restricted dams but was reduced in food restricted-ad libitum dams. These results extend to the preweaning period our previous finding that past or current food restriction impairs reproductive success and decreases milk yield in rats.

Original languageEnglish (US)
Pages (from-to)2400-2406
Number of pages7
JournalJournal of Nutrition
Volume125
Issue number9
StatePublished - 1995
Externally publishedYes

Fingerprint

milk yield
Milk
pups
milk
Food
litter weight
lactation
rats
weaning
Lactation
diet
nutrient availability
malnutrition
food intake
pregnancy
Weaning
Weights and Measures
reproductive success
Diet
Malnutrition

Keywords

  • lactation
  • milk
  • nutrition
  • rats
  • reproduction

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Pre- and postweaning food restrictions interact to determine reproductive success and milk volume in rats. / McGuire, M. K.; Littleton, Andrea W.; Schulze, K. J.; Rasmussen, K. M.

In: Journal of Nutrition, Vol. 125, No. 9, 1995, p. 2400-2406.

Research output: Contribution to journalArticle

McGuire, M. K. ; Littleton, Andrea W. ; Schulze, K. J. ; Rasmussen, K. M. / Pre- and postweaning food restrictions interact to determine reproductive success and milk volume in rats. In: Journal of Nutrition. 1995 ; Vol. 125, No. 9. pp. 2400-2406.
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