Practical recommendations for the use of ACE inhibitors, beta-blockers, aldosterone antagonists and angiotensin receptor blockers in heart failure: Putting guidelines into practice

John McMurray, Alain Cohen-Solal, Rainer Dietz, Eric Eichhorn, Leif Erhardt, F. D.Richard Hobbs, Henry Krum, Aldo Maggioni, Robert S. McKelvie, Ileana L. Piña, Jordi Soler-Soler, Karl Swedberg

Research output: Contribution to journalReview article

111 Scopus citations

Abstract

Surveys of prescribing patterns in both hospitals and primary care have usually shown delays in translating the evidence from clinical trials of pharmacological agents into clinical practice, thereby denying patients with heart failure (HF) the benefits of drug treatments proven to improve well-being and prolong life. This may be due to unfamiliarity with the evidence-base for these therapies, the clinical guidelines recommending the use of these treatments or both, as well as concerns regarding adverse events. ACE inhibitors have long been the cornerstone of therapy for systolic HF irrespective of aetiology. Recent trials have now shown that treatment with beta-blockers, aldosterone antagonists and angiotensin receptor blockers also leads to substantial improvements in outcome. In order to accelerate the safe uptake of these treatments and to ensure that all eligible patients receive the most appropriate medications, a clear and concise set of clinical recommendations has been prepared by a group of clinicians with practical expertise in the management of HF. The objective of these recommendations is to provide practical guidance for non-specialists, in order to increase the use of evidenced based therapy for HF. These practical recommendations are meant to serve as a supplement to, rather than replacement of, existing HF guidelines.

Original languageEnglish (US)
Pages (from-to)710-721
Number of pages12
JournalEuropean Journal of Heart Failure
Volume7
Issue number5
DOIs
StatePublished - Aug 1 2005

Keywords

  • ACE inhibitors
  • Aldosterone antagonists
  • Angiotensin receptor blockers
  • Beta-blockers
  • Clinical recommendations
  • Digoxin
  • Eplerenone
  • Heart failure
  • Hydralazine
  • Isosorbide dinitrate
  • Pharmacology
  • Spironolactone
  • Treatment

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    McMurray, J., Cohen-Solal, A., Dietz, R., Eichhorn, E., Erhardt, L., Hobbs, F. D. R., Krum, H., Maggioni, A., McKelvie, R. S., Piña, I. L., Soler-Soler, J., & Swedberg, K. (2005). Practical recommendations for the use of ACE inhibitors, beta-blockers, aldosterone antagonists and angiotensin receptor blockers in heart failure: Putting guidelines into practice. European Journal of Heart Failure, 7(5), 710-721. https://doi.org/10.1016/j.ejheart.2005.07.002