Potentiation of radiation effects on two murine tumors by lonidamine

J. H. Kim, A. A. Alfieri, S. H. Kim, C. W. Young

Research output: Contribution to journalArticle

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Abstract

Lonidamine is a potent inhibitor of spermatogenesis and a hyperthermic sensitizer. The principal established locus of biochemical action of lonidamine is a selective inhibitory effect of the energy metabolism either in NAD-linked reactions in germ cell mitochondria, as well as the glycolytic metabolism of a variety of tumor cell lines by means of inhibition of mitochondrially bound hexokinase. We carried out in vivo tumor experiments to determine whether lonidamine when combined with radiation could potentiate the cytotoxic effects of radiation on two murine tumors. The combined effects of single acute lonidamine (100 mg/kg) and single dose X-irradiation were evaluated on the transplanted methylcholanthrene-induced fibrosarcoma in BALB/c mice and on the radiation-induced fibrosarcoma in C3H/He mice. The radiosensitizing effect by lonidamine was maximal when lonidamine was administered immediately prior to or after X-irradiation. The dose modifying factor of lonidamine is estimated to be 1.36 for methylcholanthrene-induced fibrosarcoma tumors and 1.25 for radiation-induced fibrosarcoma tumors. There was no disproportionately enhanced skin reaction following the combined treatments. The present results of the potentiating effects of radiation may be attributed, in part, to the findings of cell cultures studies that lonidamine is a potent inhibitor of repair of potentially lethal damage.

Original languageEnglish (US)
Pages (from-to)1120-1123
Number of pages4
JournalCancer Research
Volume46
Issue number3
StatePublished - 1986
Externally publishedYes

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Radiation Effects
Fibrosarcoma
Neoplasms
Methylcholanthrene
Radiation
Radiation-Sensitizing Agents
Hexokinase
lonidamine
Inbred C3H Mouse
Spermatogenesis
Tumor Cell Line
Germ Cells
NAD
Energy Metabolism
Mitochondria
Cell Culture Techniques
Skin

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Kim, J. H., Alfieri, A. A., Kim, S. H., & Young, C. W. (1986). Potentiation of radiation effects on two murine tumors by lonidamine. Cancer Research, 46(3), 1120-1123.

Potentiation of radiation effects on two murine tumors by lonidamine. / Kim, J. H.; Alfieri, A. A.; Kim, S. H.; Young, C. W.

In: Cancer Research, Vol. 46, No. 3, 1986, p. 1120-1123.

Research output: Contribution to journalArticle

Kim, JH, Alfieri, AA, Kim, SH & Young, CW 1986, 'Potentiation of radiation effects on two murine tumors by lonidamine', Cancer Research, vol. 46, no. 3, pp. 1120-1123.
Kim JH, Alfieri AA, Kim SH, Young CW. Potentiation of radiation effects on two murine tumors by lonidamine. Cancer Research. 1986;46(3):1120-1123.
Kim, J. H. ; Alfieri, A. A. ; Kim, S. H. ; Young, C. W. / Potentiation of radiation effects on two murine tumors by lonidamine. In: Cancer Research. 1986 ; Vol. 46, No. 3. pp. 1120-1123.
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