Potentiation of Electrical and Chemical Synaptic Transmission Mediated by Endocannabinoids

Roger Cachope, Ken Mackie, Antoine Triller, John O'Brien, Alberto E. Pereda

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Endocannabinoids are well established as inhibitors of chemical synaptic transmission via presynaptic activation of the cannabinoid type 1 receptor (CB1R). Contrasting this notion, we show that dendritic release of endocannabinoids mediates potentiation of synaptic transmission at mixed (electrical and chemical) synaptic contacts on the goldfish Mauthner cell. Remarkably, the observed enhancement was not restricted to the glutamatergic component of the synaptic response but also included a parallel increase in electrical transmission. This effect involved the activation of CB1 receptors and was indirectly mediated via the release of dopamine from nearby varicosities, which in turn led to potentiation of the synaptic response via a cAMP-dependent protein kinase-mediated postsynaptic mechanism. Thus, endocannabinoid release can potentiate synaptic transmission, and its functional roles include the regulation of gap junction-mediated electrical synapses. Similar interactions between endocannabinoid and dopaminergic systems may be widespread and potentially relevant for the motor and rewarding effects of cannabis derivatives.

Original languageEnglish (US)
Pages (from-to)1034-1047
Number of pages14
JournalNeuron
Volume56
Issue number6
DOIs
StatePublished - Dec 20 2007

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Endocannabinoids
Synaptic Transmission
Electrical Synapses
Cannabinoid Receptor CB1
Cannabinoid Receptors
Goldfish
Gap Junctions
Cannabis
Cyclic AMP-Dependent Protein Kinases
Dopamine

Keywords

  • MOLNEURO

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Potentiation of Electrical and Chemical Synaptic Transmission Mediated by Endocannabinoids. / Cachope, Roger; Mackie, Ken; Triller, Antoine; O'Brien, John; Pereda, Alberto E.

In: Neuron, Vol. 56, No. 6, 20.12.2007, p. 1034-1047.

Research output: Contribution to journalArticle

Cachope, Roger ; Mackie, Ken ; Triller, Antoine ; O'Brien, John ; Pereda, Alberto E. / Potentiation of Electrical and Chemical Synaptic Transmission Mediated by Endocannabinoids. In: Neuron. 2007 ; Vol. 56, No. 6. pp. 1034-1047.
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