TY - JOUR
T1 - Potassium-Induced Lesions of the Small Bowel
T2 - II. Pathology and Pathogenesis
AU - Allen, Arthur C.
AU - Boley, Scott J.
AU - Schultz, Leon
AU - Schwartz, Solomon
PY - 1965/9/20
Y1 - 1965/9/20
N2 - The etiologic role of potassium in the development of characteristically circumferential, stenosing ulcers of the small bowel has been previously inferred and is now established as fact. Precisely how the potassium effects ulcerogenesis is the subject of this communication. The conclusion that an orally administered agent ulcerates the intestine by a topical, escharotic action is the natural one but the morphological and physiological evidence does not substantiate it. In our judgment, the lesion is essentially a hemorrhagic infarct which, depending on its extent and fulminance, produces edema, hemorrhage, erosion, perforation, or cicatrizing stenosis. In the majority of instances, an antedating or perhaps, concomitant organic change in the appertaining vessels may contribute to the vascular insufficiency. In other instances, the vascular insufficiency in both humans and in the experimental animal appears to occur on a functional, probably venomotor, basis and is reflected in segmental hemorrhagic infarctions.
AB - The etiologic role of potassium in the development of characteristically circumferential, stenosing ulcers of the small bowel has been previously inferred and is now established as fact. Precisely how the potassium effects ulcerogenesis is the subject of this communication. The conclusion that an orally administered agent ulcerates the intestine by a topical, escharotic action is the natural one but the morphological and physiological evidence does not substantiate it. In our judgment, the lesion is essentially a hemorrhagic infarct which, depending on its extent and fulminance, produces edema, hemorrhage, erosion, perforation, or cicatrizing stenosis. In the majority of instances, an antedating or perhaps, concomitant organic change in the appertaining vessels may contribute to the vascular insufficiency. In other instances, the vascular insufficiency in both humans and in the experimental animal appears to occur on a functional, probably venomotor, basis and is reflected in segmental hemorrhagic infarctions.
UR - http://www.scopus.com/inward/record.url?scp=6844263351&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=6844263351&partnerID=8YFLogxK
U2 - 10.1001/jama.1965.03090120009003
DO - 10.1001/jama.1965.03090120009003
M3 - Article
C2 - 14338797
AN - SCOPUS:6844263351
SN - 0098-7484
VL - 193
SP - 1001
EP - 1006
JO - JAMA: The Journal of the American Medical Association
JF - JAMA: The Journal of the American Medical Association
IS - 12
ER -