Posttranslational modifications of Tubulin

Suzan K. Chao; Chia Ping H. Yang; Susan Band Horwitz

doi:10.1007/978-1-61779-788-0_13

Posttranslational modifications of Tubulin

Suzan K. Chao, Chia Ping H. Yang, Susan Band Horwitz

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Abstract

Recent studies have highlighted the potential importance of posttranslational modifications of tubulin in dictating response to antitumor drugs and disease progression. These modifications include glutamylation, glycylation, phosphorylation, acetylation, and tyrosination. Some of the tubulin-modifying enzymes have been identified but the functional consequences of the posttranslational modifications remain largely unknown. In this chapter, we review the posttranslational modifications of tubulin and current knowledge of the role these alterations may play in human disease.

Original language	English (US)
Title of host publication	Cytoskeleton and Human Disease
Publisher	Humana Press Inc.
Pages	241-257
Number of pages	17
Volume	9781617797880
ISBN (Electronic)	9781617797880
ISBN (Print)	1617797871, 9781617797873
DOIs	https://doi.org/10.1007/978-1-61779-788-0_13
State	Published - Dec 1 2012

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-1-61779-788-0_13

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title = "Posttranslational modifications of Tubulin",

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AU - Yang, Chia Ping H.

AU - Horwitz, Susan Band

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AB - Recent studies have highlighted the potential importance of posttranslational modifications of tubulin in dictating response to antitumor drugs and disease progression. These modifications include glutamylation, glycylation, phosphorylation, acetylation, and tyrosination. Some of the tubulin-modifying enzymes have been identified but the functional consequences of the posttranslational modifications remain largely unknown. In this chapter, we review the posttranslational modifications of tubulin and current knowledge of the role these alterations may play in human disease.

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PB - Humana Press Inc.

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Posttranslational modifications of Tubulin

Abstract

ASJC Scopus subject areas

UN SDGs

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