Posttranslational Modifications in Algae: Role in Stress Response and Biopharmaceutical Production

Parvez Ahmad, Fareha Bano

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Posttranslational modification (PTM), a key process for the functional diversity of proteins, plays a crucial role in regulation and maintenance of various processes of the cell, including metabolism, recognition, morphological changes, defense, protein conformation and integrity, etc. Although in algae, induction of stress genes at transcription level significantly contributes to the defense system of the cell, PTMs directly regulate the activities of preexisting stress proteins with rapid responses. Among all PTMs reported in algae in response to stress, the most common are phosphorylation, ubiquitination, and SUMOylation. Glycosylation and di-sulfide bond play an essential role in manufacturing therapeutic proteins due to their involvement in protein folding and function. In fact, in algae, PTMs are manifested to contribute to various parameters that have immense influence on the endogenous protein biology, stress responses, and protein based/derived therapeutics. In this chapter, we have tried to summarize the importance and application of major and well-studied PTMs in relation to stress responses as well as therapeutics in algae.

Original languageEnglish (US)
Title of host publicationProtein Modificomics
Subtitle of host publicationFrom Modifications to Clinical Perspectives
PublisherElsevier
Pages313-337
Number of pages25
ISBN (Electronic)9780128119136
ISBN (Print)9780128119501
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

Keywords

  • Glycosylation
  • Phosphorylation
  • PTM
  • Stress responses
  • Therapeutic proteins
  • Ubiquitination

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint

Dive into the research topics of 'Posttranslational Modifications in Algae: Role in Stress Response and Biopharmaceutical Production'. Together they form a unique fingerprint.

Cite this