Postthaw blastomere survival is predictive of the success of frozen-thawed embryo transfer cycles

Lubna Pal, Peter Kovacs, Barry Witt, Sangita K. Jindal, Nanette Santoro, David Barad

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

To investigate the predictors of postthaw blastomere survival and the relationship of blastomere survival to the outcome of frozen-thawed embryo transfer (FET) cycles. Retrospective study. An IVF unit in a tertiary care facility. Infertile women undergoing FET cycles with embryos cryopreserved on day 3 postinsemination. FET cycles. Embryo survival postthaw, pregnancy (PR), clinical pregnancy, and implantation rates. A significant impact of postthaw blastomere survival on the outcome of FET cycles was noted. The thawed embryos in the low survival tertile resulted in significantly impaired implantation rate, clinical pregnancy rate, and PR compared to embryos in the high survival tertile. An inverse association was noted between serum P levels on the day of hCG administration and postthaw blastomere survival. We have demonstrated that postthaw blastomere survival is predictive of success of FET cycles. The relationship of poor postthaw embryo survival in the setting of elevated P is novel and not hitherto described.

Original languageEnglish (US)
Pages (from-to)821-826
Number of pages6
JournalFertility and Sterility
Volume82
Issue number4
DOIs
StatePublished - Oct 2004
Externally publishedYes

Fingerprint

Blastomeres
Embryo Transfer
Survival
Embryonic Structures
Pregnancy Rate
Pregnancy
Tertiary Healthcare
Retrospective Studies

Keywords

  • blastomere
  • cryopreservation
  • Embryo
  • FET
  • IVF
  • survival

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Postthaw blastomere survival is predictive of the success of frozen-thawed embryo transfer cycles. / Pal, Lubna; Kovacs, Peter; Witt, Barry; Jindal, Sangita K.; Santoro, Nanette; Barad, David.

In: Fertility and Sterility, Vol. 82, No. 4, 10.2004, p. 821-826.

Research output: Contribution to journalArticle

Pal, Lubna ; Kovacs, Peter ; Witt, Barry ; Jindal, Sangita K. ; Santoro, Nanette ; Barad, David. / Postthaw blastomere survival is predictive of the success of frozen-thawed embryo transfer cycles. In: Fertility and Sterility. 2004 ; Vol. 82, No. 4. pp. 821-826.
@article{b71f6df54b9644b49133e8098f1f712d,
title = "Postthaw blastomere survival is predictive of the success of frozen-thawed embryo transfer cycles",
abstract = "To investigate the predictors of postthaw blastomere survival and the relationship of blastomere survival to the outcome of frozen-thawed embryo transfer (FET) cycles. Retrospective study. An IVF unit in a tertiary care facility. Infertile women undergoing FET cycles with embryos cryopreserved on day 3 postinsemination. FET cycles. Embryo survival postthaw, pregnancy (PR), clinical pregnancy, and implantation rates. A significant impact of postthaw blastomere survival on the outcome of FET cycles was noted. The thawed embryos in the low survival tertile resulted in significantly impaired implantation rate, clinical pregnancy rate, and PR compared to embryos in the high survival tertile. An inverse association was noted between serum P levels on the day of hCG administration and postthaw blastomere survival. We have demonstrated that postthaw blastomere survival is predictive of success of FET cycles. The relationship of poor postthaw embryo survival in the setting of elevated P is novel and not hitherto described.",
keywords = "blastomere, cryopreservation, Embryo, FET, IVF, survival",
author = "Lubna Pal and Peter Kovacs and Barry Witt and Jindal, {Sangita K.} and Nanette Santoro and David Barad",
year = "2004",
month = "10",
doi = "10.1016/j.fertnstert.2004.02.136",
language = "English (US)",
volume = "82",
pages = "821--826",
journal = "Fertility and Sterility",
issn = "0015-0282",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Postthaw blastomere survival is predictive of the success of frozen-thawed embryo transfer cycles

AU - Pal, Lubna

AU - Kovacs, Peter

AU - Witt, Barry

AU - Jindal, Sangita K.

AU - Santoro, Nanette

AU - Barad, David

PY - 2004/10

Y1 - 2004/10

N2 - To investigate the predictors of postthaw blastomere survival and the relationship of blastomere survival to the outcome of frozen-thawed embryo transfer (FET) cycles. Retrospective study. An IVF unit in a tertiary care facility. Infertile women undergoing FET cycles with embryos cryopreserved on day 3 postinsemination. FET cycles. Embryo survival postthaw, pregnancy (PR), clinical pregnancy, and implantation rates. A significant impact of postthaw blastomere survival on the outcome of FET cycles was noted. The thawed embryos in the low survival tertile resulted in significantly impaired implantation rate, clinical pregnancy rate, and PR compared to embryos in the high survival tertile. An inverse association was noted between serum P levels on the day of hCG administration and postthaw blastomere survival. We have demonstrated that postthaw blastomere survival is predictive of success of FET cycles. The relationship of poor postthaw embryo survival in the setting of elevated P is novel and not hitherto described.

AB - To investigate the predictors of postthaw blastomere survival and the relationship of blastomere survival to the outcome of frozen-thawed embryo transfer (FET) cycles. Retrospective study. An IVF unit in a tertiary care facility. Infertile women undergoing FET cycles with embryos cryopreserved on day 3 postinsemination. FET cycles. Embryo survival postthaw, pregnancy (PR), clinical pregnancy, and implantation rates. A significant impact of postthaw blastomere survival on the outcome of FET cycles was noted. The thawed embryos in the low survival tertile resulted in significantly impaired implantation rate, clinical pregnancy rate, and PR compared to embryos in the high survival tertile. An inverse association was noted between serum P levels on the day of hCG administration and postthaw blastomere survival. We have demonstrated that postthaw blastomere survival is predictive of success of FET cycles. The relationship of poor postthaw embryo survival in the setting of elevated P is novel and not hitherto described.

KW - blastomere

KW - cryopreservation

KW - Embryo

KW - FET

KW - IVF

KW - survival

UR - http://www.scopus.com/inward/record.url?scp=5144222810&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=5144222810&partnerID=8YFLogxK

U2 - 10.1016/j.fertnstert.2004.02.136

DO - 10.1016/j.fertnstert.2004.02.136

M3 - Article

C2 - 15482754

AN - SCOPUS:5144222810

VL - 82

SP - 821

EP - 826

JO - Fertility and Sterility

JF - Fertility and Sterility

SN - 0015-0282

IS - 4

ER -