Postprimary tuberculosis and macrophage necrosis: Is there a big conNECtion?

Ka Wing Wong, William R. Jacobs

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Adult or postprimary tuberculosis (TB) accounts for most TB cases. Its hallmark is pulmonary cavitation, which occurs as a result of necrosis in the lung in individuals with tuberculous pneumonia. Postprimary TB has previously been known to be associated with vascular thrombosis and delayed-type hypersensitivity, but their roles in pulmonary cavitation are unclear. A necrosis-associated extracellular cluster (NEC) refers to a cluster of drug-tolerant Mycobacterium tuberculosis attached to lysed host materials and is proposed to contribute to granulomatous TB. Here we suggest that NECs, perhaps due to big size, produce a distinct host response leading to postprimary TB. We propose that vascular thrombosis and pneumonia arise from NEC and that these processes are promoted by inflammatory cytokines produced from cell-mediated delayed-type hypersensitivity, such as interleukin-17 and gamma interferon, eventually triggering necrosis in the lung and causing cavitation. According to this view, targeting NEC represents a necessary strategy to control adult TB.

Original languageEnglish (US)
Article numbere01589-15
JournalmBio
Volume7
Issue number1
DOIs
StatePublished - Jan 12 2016

ASJC Scopus subject areas

  • Microbiology
  • Virology

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