Postmenopausal endogenous oestrogens and risk of endometrial cancer: Results of a prospective study

A. Zeleniuch-Jacquotte, A. Akhmedkhanov, I. Kato, K. L. Koenig, R. E. Shore, Mimi Kim, M. Levitz, K. R. Mittal, U. Raju, S. Banerjee, P. Toniolo

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

We assessed the association of postmenopausal serum levels of oestrogens and sex hormone-binding globulin (SHBG) with endometrial cancer risk in a case-control study nested within the NYU Women's Health Study cohort. Among 7054 women postmenopausal at enrolment, 57 cases of endometrial cancer were diagnosed a median of 5.5 years after blood donation. Each case was compared to 4 controls matched on age, menopausal status at enrolment, and serum storage duration. Endometrial cancer risk increased with higher levels of oestradiol (odds ratio = 2.4 in highest vs lowest tertile, P for trend = 0.02), percent free oestradiol (OR = 3.5, P < 0.001), and oestrone (OR = 3.9, P < 0.001). Risk decreased with higher levels of percent SHBG-bound oestradiol (OR = 0.43, P = 0.03) and SHBG (OR = 0.39, P = 0.01). Trends remained in the same directions after adjusting for height and body mass index. A positive association of body mass index with risk was substantially reduced after adjusting for oestrone level. Our results indicate that risk of endometrial cancer increases with increasing postmenopausal oestrogen levels but do not provide strong support for a role of body mass index independent of its effect on oestrogen levels.

Original languageEnglish (US)
Pages (from-to)975-981
Number of pages7
JournalBritish Journal of Cancer
Volume84
Issue number7
DOIs
StatePublished - Apr 6 2001
Externally publishedYes

Fingerprint

Endometrial Neoplasms
Estrogens
Sex Hormone-Binding Globulin
Prospective Studies
Estradiol
Body Mass Index
Estrone
Women's Health
Blood Donors
Serum
Case-Control Studies
Cohort Studies
Odds Ratio

Keywords

  • Body mass index
  • Endometrial cancer
  • Nested case-control study
  • Oestradiol
  • Oestrogen
  • SHBG

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Zeleniuch-Jacquotte, A., Akhmedkhanov, A., Kato, I., Koenig, K. L., Shore, R. E., Kim, M., ... Toniolo, P. (2001). Postmenopausal endogenous oestrogens and risk of endometrial cancer: Results of a prospective study. British Journal of Cancer, 84(7), 975-981. https://doi.org/10.1054/bjoc.2001.1704

Postmenopausal endogenous oestrogens and risk of endometrial cancer : Results of a prospective study. / Zeleniuch-Jacquotte, A.; Akhmedkhanov, A.; Kato, I.; Koenig, K. L.; Shore, R. E.; Kim, Mimi; Levitz, M.; Mittal, K. R.; Raju, U.; Banerjee, S.; Toniolo, P.

In: British Journal of Cancer, Vol. 84, No. 7, 06.04.2001, p. 975-981.

Research output: Contribution to journalArticle

Zeleniuch-Jacquotte, A, Akhmedkhanov, A, Kato, I, Koenig, KL, Shore, RE, Kim, M, Levitz, M, Mittal, KR, Raju, U, Banerjee, S & Toniolo, P 2001, 'Postmenopausal endogenous oestrogens and risk of endometrial cancer: Results of a prospective study', British Journal of Cancer, vol. 84, no. 7, pp. 975-981. https://doi.org/10.1054/bjoc.2001.1704
Zeleniuch-Jacquotte, A. ; Akhmedkhanov, A. ; Kato, I. ; Koenig, K. L. ; Shore, R. E. ; Kim, Mimi ; Levitz, M. ; Mittal, K. R. ; Raju, U. ; Banerjee, S. ; Toniolo, P. / Postmenopausal endogenous oestrogens and risk of endometrial cancer : Results of a prospective study. In: British Journal of Cancer. 2001 ; Vol. 84, No. 7. pp. 975-981.
@article{f40d5724951046448b0b3f6faee9f1db,
title = "Postmenopausal endogenous oestrogens and risk of endometrial cancer: Results of a prospective study",
abstract = "We assessed the association of postmenopausal serum levels of oestrogens and sex hormone-binding globulin (SHBG) with endometrial cancer risk in a case-control study nested within the NYU Women's Health Study cohort. Among 7054 women postmenopausal at enrolment, 57 cases of endometrial cancer were diagnosed a median of 5.5 years after blood donation. Each case was compared to 4 controls matched on age, menopausal status at enrolment, and serum storage duration. Endometrial cancer risk increased with higher levels of oestradiol (odds ratio = 2.4 in highest vs lowest tertile, P for trend = 0.02), percent free oestradiol (OR = 3.5, P < 0.001), and oestrone (OR = 3.9, P < 0.001). Risk decreased with higher levels of percent SHBG-bound oestradiol (OR = 0.43, P = 0.03) and SHBG (OR = 0.39, P = 0.01). Trends remained in the same directions after adjusting for height and body mass index. A positive association of body mass index with risk was substantially reduced after adjusting for oestrone level. Our results indicate that risk of endometrial cancer increases with increasing postmenopausal oestrogen levels but do not provide strong support for a role of body mass index independent of its effect on oestrogen levels.",
keywords = "Body mass index, Endometrial cancer, Nested case-control study, Oestradiol, Oestrogen, SHBG",
author = "A. Zeleniuch-Jacquotte and A. Akhmedkhanov and I. Kato and Koenig, {K. L.} and Shore, {R. E.} and Mimi Kim and M. Levitz and Mittal, {K. R.} and U. Raju and S. Banerjee and P. Toniolo",
year = "2001",
month = "4",
day = "6",
doi = "10.1054/bjoc.2001.1704",
language = "English (US)",
volume = "84",
pages = "975--981",
journal = "British Journal of Cancer",
issn = "0007-0920",
publisher = "Nature Publishing Group",
number = "7",

}

TY - JOUR

T1 - Postmenopausal endogenous oestrogens and risk of endometrial cancer

T2 - Results of a prospective study

AU - Zeleniuch-Jacquotte, A.

AU - Akhmedkhanov, A.

AU - Kato, I.

AU - Koenig, K. L.

AU - Shore, R. E.

AU - Kim, Mimi

AU - Levitz, M.

AU - Mittal, K. R.

AU - Raju, U.

AU - Banerjee, S.

AU - Toniolo, P.

PY - 2001/4/6

Y1 - 2001/4/6

N2 - We assessed the association of postmenopausal serum levels of oestrogens and sex hormone-binding globulin (SHBG) with endometrial cancer risk in a case-control study nested within the NYU Women's Health Study cohort. Among 7054 women postmenopausal at enrolment, 57 cases of endometrial cancer were diagnosed a median of 5.5 years after blood donation. Each case was compared to 4 controls matched on age, menopausal status at enrolment, and serum storage duration. Endometrial cancer risk increased with higher levels of oestradiol (odds ratio = 2.4 in highest vs lowest tertile, P for trend = 0.02), percent free oestradiol (OR = 3.5, P < 0.001), and oestrone (OR = 3.9, P < 0.001). Risk decreased with higher levels of percent SHBG-bound oestradiol (OR = 0.43, P = 0.03) and SHBG (OR = 0.39, P = 0.01). Trends remained in the same directions after adjusting for height and body mass index. A positive association of body mass index with risk was substantially reduced after adjusting for oestrone level. Our results indicate that risk of endometrial cancer increases with increasing postmenopausal oestrogen levels but do not provide strong support for a role of body mass index independent of its effect on oestrogen levels.

AB - We assessed the association of postmenopausal serum levels of oestrogens and sex hormone-binding globulin (SHBG) with endometrial cancer risk in a case-control study nested within the NYU Women's Health Study cohort. Among 7054 women postmenopausal at enrolment, 57 cases of endometrial cancer were diagnosed a median of 5.5 years after blood donation. Each case was compared to 4 controls matched on age, menopausal status at enrolment, and serum storage duration. Endometrial cancer risk increased with higher levels of oestradiol (odds ratio = 2.4 in highest vs lowest tertile, P for trend = 0.02), percent free oestradiol (OR = 3.5, P < 0.001), and oestrone (OR = 3.9, P < 0.001). Risk decreased with higher levels of percent SHBG-bound oestradiol (OR = 0.43, P = 0.03) and SHBG (OR = 0.39, P = 0.01). Trends remained in the same directions after adjusting for height and body mass index. A positive association of body mass index with risk was substantially reduced after adjusting for oestrone level. Our results indicate that risk of endometrial cancer increases with increasing postmenopausal oestrogen levels but do not provide strong support for a role of body mass index independent of its effect on oestrogen levels.

KW - Body mass index

KW - Endometrial cancer

KW - Nested case-control study

KW - Oestradiol

KW - Oestrogen

KW - SHBG

UR - http://www.scopus.com/inward/record.url?scp=17744376755&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=17744376755&partnerID=8YFLogxK

U2 - 10.1054/bjoc.2001.1704

DO - 10.1054/bjoc.2001.1704

M3 - Article

C2 - 11286480

AN - SCOPUS:17744376755

VL - 84

SP - 975

EP - 981

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

IS - 7

ER -