Abstract
The prevalence of post-traumatic stress disorder (PTSD) is higher among HIV-infected (HIV+) women compared with HIV-uninfected (HIV−) women, and deficits in episodic memory are a common feature of both PTSD and HIV infection. We investigated the association between a probable PTSD diagnosis using the PTSD Checklist-Civilian (PCL-C) version and verbal learning and memory using the Hopkins Verbal Learning Test in 1004 HIV+ and 496 at-risk HIV− women. HIV infection was not associated with a probable PTSD diagnosis (17 % HIV+, 16 % HIV−; p = 0.49) but was associated with lower verbal learning (p <0.01) and memory scores (p <0.01). Irrespective of HIV status, a probable PTSD diagnosis was associated with poorer performance in verbal learning (p <0.01) and memory (p <0.01) and psychomotor speed (p <0.001). The particular pattern of cognitive correlates of probable PTSD varied depending on exposure to sexual abuse and/or violence, with exposure to either being associated with a greater number of cognitive domains and a worse cognitive profile. A statistical interaction between HIV serostatus and PTSD was observed on the fine motor skills domain (p = 0.03). Among women with probable PTSD, HIV− women performed worse than HIV+ women on fine motor skills (p = 0.01), but among women without probable PTSD, there was no significant difference in performance between the groups (p = 0.59). These findings underscore the importance of considering mental health factors as correlates to cognitive deficits in women with HIV.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 159-169 |
| Number of pages | 11 |
| Journal | Journal of NeuroVirology |
| Volume | 22 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 1 2016 |
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Keywords
- Cognition
- HIV
- Post-traumatic stress disorder
- Women
ASJC Scopus subject areas
- Virology
- Clinical Neurology
- Cellular and Molecular Neuroscience
- Neurology
Cite this
Post-traumatic stress is associated with verbal learning, memory, and psychomotor speed in HIV-infected and HIV-uninfected women. / Rubin, Leah H.; Pyra, Maria; Cook, Judith A.; Weber, Kathleen M.; Cohen, Mardge H.; Martin, Eileen; Valcour, Victor; Milam, Joel; Anastos, Kathryn; Young, Mary A.; Alden, Christine; Gustafson, Deborah R.; Maki, Pauline M.
In: Journal of NeuroVirology, Vol. 22, No. 2, 01.04.2016, p. 159-169.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Post-traumatic stress is associated with verbal learning, memory, and psychomotor speed in HIV-infected and HIV-uninfected women
AU - Rubin, Leah H.
AU - Pyra, Maria
AU - Cook, Judith A.
AU - Weber, Kathleen M.
AU - Cohen, Mardge H.
AU - Martin, Eileen
AU - Valcour, Victor
AU - Milam, Joel
AU - Anastos, Kathryn
AU - Young, Mary A.
AU - Alden, Christine
AU - Gustafson, Deborah R.
AU - Maki, Pauline M.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - The prevalence of post-traumatic stress disorder (PTSD) is higher among HIV-infected (HIV+) women compared with HIV-uninfected (HIV−) women, and deficits in episodic memory are a common feature of both PTSD and HIV infection. We investigated the association between a probable PTSD diagnosis using the PTSD Checklist-Civilian (PCL-C) version and verbal learning and memory using the Hopkins Verbal Learning Test in 1004 HIV+ and 496 at-risk HIV− women. HIV infection was not associated with a probable PTSD diagnosis (17 % HIV+, 16 % HIV−; p = 0.49) but was associated with lower verbal learning (p <0.01) and memory scores (p <0.01). Irrespective of HIV status, a probable PTSD diagnosis was associated with poorer performance in verbal learning (p <0.01) and memory (p <0.01) and psychomotor speed (p <0.001). The particular pattern of cognitive correlates of probable PTSD varied depending on exposure to sexual abuse and/or violence, with exposure to either being associated with a greater number of cognitive domains and a worse cognitive profile. A statistical interaction between HIV serostatus and PTSD was observed on the fine motor skills domain (p = 0.03). Among women with probable PTSD, HIV− women performed worse than HIV+ women on fine motor skills (p = 0.01), but among women without probable PTSD, there was no significant difference in performance between the groups (p = 0.59). These findings underscore the importance of considering mental health factors as correlates to cognitive deficits in women with HIV.
AB - The prevalence of post-traumatic stress disorder (PTSD) is higher among HIV-infected (HIV+) women compared with HIV-uninfected (HIV−) women, and deficits in episodic memory are a common feature of both PTSD and HIV infection. We investigated the association between a probable PTSD diagnosis using the PTSD Checklist-Civilian (PCL-C) version and verbal learning and memory using the Hopkins Verbal Learning Test in 1004 HIV+ and 496 at-risk HIV− women. HIV infection was not associated with a probable PTSD diagnosis (17 % HIV+, 16 % HIV−; p = 0.49) but was associated with lower verbal learning (p <0.01) and memory scores (p <0.01). Irrespective of HIV status, a probable PTSD diagnosis was associated with poorer performance in verbal learning (p <0.01) and memory (p <0.01) and psychomotor speed (p <0.001). The particular pattern of cognitive correlates of probable PTSD varied depending on exposure to sexual abuse and/or violence, with exposure to either being associated with a greater number of cognitive domains and a worse cognitive profile. A statistical interaction between HIV serostatus and PTSD was observed on the fine motor skills domain (p = 0.03). Among women with probable PTSD, HIV− women performed worse than HIV+ women on fine motor skills (p = 0.01), but among women without probable PTSD, there was no significant difference in performance between the groups (p = 0.59). These findings underscore the importance of considering mental health factors as correlates to cognitive deficits in women with HIV.
KW - Cognition
KW - HIV
KW - Post-traumatic stress disorder
KW - Women
UR - http://www.scopus.com/inward/record.url?scp=84960802274&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84960802274&partnerID=8YFLogxK
U2 - 10.1007/s13365-015-0380-9
DO - 10.1007/s13365-015-0380-9
M3 - Article
C2 - 26404435
AN - SCOPUS:84960802274
VL - 22
SP - 159
EP - 169
JO - Journal of NeuroVirology
JF - Journal of NeuroVirology
SN - 1355-0284
IS - 2
ER -