Possible effect of maternal promethazine therapy on neonatal immunologic functions

Arye Rubinstein, Arthur I. Eidelman, Julian Melamed, Lawrence M. Gartner, Stephen Kandall, Harold Schulman

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The effect of the administration of promethazine in the treatment of erythroblastosis fetalis was studied in four maternal-fetal pairs. The three infants exposed for a prolonged period of time had decreased neonatal number and function of T cells, and abnormal specific humoral immune responses. The possible role of promethazine in the induction of fetal immunoincompetence is discussed.

Original languageEnglish (US)
Pages (from-to)136-138
Number of pages3
JournalThe Journal of Pediatrics
Volume89
Issue number1
DOIs
StatePublished - 1976

Fingerprint

Promethazine
Mothers
Fetal Erythroblastosis
Humoral Immunity
T-Lymphocytes
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Possible effect of maternal promethazine therapy on neonatal immunologic functions. / Rubinstein, Arye; Eidelman, Arthur I.; Melamed, Julian; Gartner, Lawrence M.; Kandall, Stephen; Schulman, Harold.

In: The Journal of Pediatrics, Vol. 89, No. 1, 1976, p. 136-138.

Research output: Contribution to journalArticle

Rubinstein, Arye ; Eidelman, Arthur I. ; Melamed, Julian ; Gartner, Lawrence M. ; Kandall, Stephen ; Schulman, Harold. / Possible effect of maternal promethazine therapy on neonatal immunologic functions. In: The Journal of Pediatrics. 1976 ; Vol. 89, No. 1. pp. 136-138.
@article{41e17a21718d4e63893f635fbd92c43e,
title = "Possible effect of maternal promethazine therapy on neonatal immunologic functions",
abstract = "The effect of the administration of promethazine in the treatment of erythroblastosis fetalis was studied in four maternal-fetal pairs. The three infants exposed for a prolonged period of time had decreased neonatal number and function of T cells, and abnormal specific humoral immune responses. The possible role of promethazine in the induction of fetal immunoincompetence is discussed.",
author = "Arye Rubinstein and Eidelman, {Arthur I.} and Julian Melamed and Gartner, {Lawrence M.} and Stephen Kandall and Harold Schulman",
year = "1976",
doi = "10.1016/S0022-3476(76)80950-X",
language = "English (US)",
volume = "89",
pages = "136--138",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",
number = "1",

}

TY - JOUR

T1 - Possible effect of maternal promethazine therapy on neonatal immunologic functions

AU - Rubinstein, Arye

AU - Eidelman, Arthur I.

AU - Melamed, Julian

AU - Gartner, Lawrence M.

AU - Kandall, Stephen

AU - Schulman, Harold

PY - 1976

Y1 - 1976

N2 - The effect of the administration of promethazine in the treatment of erythroblastosis fetalis was studied in four maternal-fetal pairs. The three infants exposed for a prolonged period of time had decreased neonatal number and function of T cells, and abnormal specific humoral immune responses. The possible role of promethazine in the induction of fetal immunoincompetence is discussed.

AB - The effect of the administration of promethazine in the treatment of erythroblastosis fetalis was studied in four maternal-fetal pairs. The three infants exposed for a prolonged period of time had decreased neonatal number and function of T cells, and abnormal specific humoral immune responses. The possible role of promethazine in the induction of fetal immunoincompetence is discussed.

UR - http://www.scopus.com/inward/record.url?scp=0017079182&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017079182&partnerID=8YFLogxK

U2 - 10.1016/S0022-3476(76)80950-X

DO - 10.1016/S0022-3476(76)80950-X

M3 - Article

VL - 89

SP - 136

EP - 138

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

IS - 1

ER -