Positive serology for Lyme borreliosis in patients with juvenile rheumatoid arthritis in a Lyme borreliosis endemic area

Analysis by immunoblot

S. K. Sood, L. G. Rubin, M. E. Blader, Norman Todd Ilowite

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Juvenile rheumatoid arthritis (JRA) and the arthritis of Lyme borreliosis in children can mimic each other. As false positive reactions are frequent in ELISA for Lyme borreliosis, they cannot be used reliably to make the distinction. Ninety-nine children diagnosed as having JRA at a children's hospital in an endemic area were evaluated by ELISA and immunoblot for antibodies to Borrelia burgdorferi. Sera from 9% were positive by ELISA, 5 of which showed bands on immunoblot. None met criteria for positive immunoblot. The antigenic basis of false positive ELISA was most frequently a reactivity to both 21 and 41 kDa. Analysis by immunoblot can help to definitively exclude Lyme borreliosis in children presenting with JRA in an endemic area.

Original languageEnglish (US)
Pages (from-to)739-741
Number of pages3
JournalJournal of Rheumatology
Volume20
Issue number4
StatePublished - 1993
Externally publishedYes

Fingerprint

Juvenile Arthritis
Lyme Disease
Serology
Enzyme-Linked Immunosorbent Assay
False Positive Reactions
Borrelia burgdorferi
Arthritis
Antibodies
Serum

Keywords

  • ELISA
  • immunoblot
  • juvenile rheumatoid arthritis
  • Lyme borreliosis

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Positive serology for Lyme borreliosis in patients with juvenile rheumatoid arthritis in a Lyme borreliosis endemic area : Analysis by immunoblot. / Sood, S. K.; Rubin, L. G.; Blader, M. E.; Ilowite, Norman Todd.

In: Journal of Rheumatology, Vol. 20, No. 4, 1993, p. 739-741.

Research output: Contribution to journalArticle

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