Positive feedback between transcriptional and kinase suppression in nematodes with extraordinary longevity and stress resistance

Medicine & Life Sciences

• Caenorhabditis elegans 14%
• Catalytic Domain 11%
• Down-Regulation 8%
• Gene Silencing 13%
• Genes 5%
• Homozygote 28%
• In Vitro Techniques 5%
• Insulin 43%
• Insulin-Like Growth Factor I 64%
• Longevity 57%
• Mammals 11%
• Membranes 7%
• MHC Class I Genes 18%
• Mutation 7%
• Nonsense Codon 14%
• Oxidative Stress 9%
• Phenotype 7%
• Phosphatidylinositol 3-Kinase 12%
• Phosphatidylinositol 3-Kinases 50%
• Phospholipids 11%
• Phosphoproteins 15%
• Phosphorylation 8%
• Phosphotransferases 49%
• Protein Kinases 11%
• Reproduction 12%
• RNA Interference 12%
• Transcription Factors 9%

Agriculture & Biology

• Caenorhabditis elegans 8%
• gene silencing 8%
• genes 5%
• homozygosity 17%
• inactivation 6%
• insulin 35%
• mammals 5%
• mutants 28%
• mutation 5%
• Nematoda 49%
• nonsense mutation 11%
• oxidative stress 6%
• phenotype 5%
• phosphatidylinositol 3-kinase 52%
• phospholipids 6%
• phosphoproteins 9%
• phosphorylation 6%
• phosphotransferases (kinases) 54%
• protein kinases 7%
• protein subunits 8%
• stress tolerance 58%
• transcription factors 6%

Earth & Environmental Sciences

• fold 5%
• gene 18%
• mammal 7%
• membrane 5%
• metabolism 6%
• mutant 50%
• mutation 15%
• nematode 71%
• oxidative stress 9%
• phenotype 8%
• phospholipid 8%
• protein 5%
• regulation 5%
• stress resistance 100%