Positive association of the human GABA-A-receptor beta 2 subunit gene haplotype with schizophrenia in the Chinese Han population

Jixia Liu, Yongyong Shi, Wei Tang, Tingwei Guo, Dawei Li, Yifeng Yang, Xinzhi Zhao, Hongsheng Wang, Xingwang Li, Guoyin Feng, Niufan Gu, Shaomin Zhu, Huijun Liu, Yangling Guo, Jianguo Shi, Hong Sang, Lijuan Yan, Lin He

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

A converging body of evidence implicates the γ-amino butyric acid neurotransmitter system in the pathogenesis of schizophrenia. Recently, Lo et al. reported strong positive association between schizophrenia and GABRB2, demonstrated by single markers and haplotypes of five markers in introns of GABRB2, rs6556547, rs1816071, rs194072, rs252944, and rs187269. To validate this linkage disequilibrium report, we genotyped these five SNPs and additional rs1816072 in 352 Chinese Han family trios. Though we failed to detect any positive results in single markers, we did find a significant haplotypic association (global p = 0.00157-0.00588) which had not been identified in Lo's study. Our data indicated that the haplotype 'GACTCT' (p = 0.00215, frequency = 53.6%) was overtransmitted which suggests that GABRB2 is in linkage disequilibrium with schizophrenia in the Chinese Han population. The difference between the two studies may be due to the respective analytic power of the two designs. These two independent studies highlighting linkage disequilibrium support the potential involvement of GABRB2 or a nearby gene in the genetic etiology of schizophrenia.

Original languageEnglish (US)
Pages (from-to)817-823
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume334
Issue number3
DOIs
StatePublished - Sep 2 2005

Keywords

  • Association
  • GABAergic neurotransmission system
  • GABRB2
  • Haplotype
  • Transmission disequilibrium

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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  • Cite this

    Liu, J., Shi, Y., Tang, W., Guo, T., Li, D., Yang, Y., Zhao, X., Wang, H., Li, X., Feng, G., Gu, N., Zhu, S., Liu, H., Guo, Y., Shi, J., Sang, H., Yan, L., & He, L. (2005). Positive association of the human GABA-A-receptor beta 2 subunit gene haplotype with schizophrenia in the Chinese Han population. Biochemical and Biophysical Research Communications, 334(3), 817-823. https://doi.org/10.1016/j.bbrc.2005.06.167