Porphyrins in Dubin-Johnson Syndrome

L. James Strand, Allan W. Wolkoff, Irwin M. Arias

Research output: Contribution to journalLetter

2 Citations (Scopus)

Abstract

To the Editor: I have some questions and comments about the article by Wolkoff et al. entitled “Inheritance of the Dubin-Johnson Syndrome” (N Engl J Med 288:113, 1973). The authors, and others previously, have observed both decreased urinary excretion of coproporphyrin III and increased excretion of coproporphyrin I in the Dubin-Johnson syndrome, yielding an abnormally high ratio of I-isomer excretion. The “obligate heterozygotes” do not conform to this pattern in that decreased III-isomer excretion is not associated with increased I-isomer excretion to yield only a 7 per cent increase in percentage of coproporphyrin I excretion vs. controls. Although the authors.

Original languageEnglish (US)
Pages (from-to)795-796
Number of pages2
JournalNew England Journal of Medicine
Volume288
Issue number15
DOIs
StatePublished - Apr 12 1973

Fingerprint

Chronic Idiopathic Jaundice
Porphyrins
Heterozygote
coproporphyrin I

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Porphyrins in Dubin-Johnson Syndrome. / Strand, L. James; Wolkoff, Allan W.; Arias, Irwin M.

In: New England Journal of Medicine, Vol. 288, No. 15, 12.04.1973, p. 795-796.

Research output: Contribution to journalLetter

Strand, L. James ; Wolkoff, Allan W. ; Arias, Irwin M. / Porphyrins in Dubin-Johnson Syndrome. In: New England Journal of Medicine. 1973 ; Vol. 288, No. 15. pp. 795-796.
@article{6a57e95ec863433b89d72ddbf380ba40,
title = "Porphyrins in Dubin-Johnson Syndrome",
abstract = "To the Editor: I have some questions and comments about the article by Wolkoff et al. entitled “Inheritance of the Dubin-Johnson Syndrome” (N Engl J Med 288:113, 1973). The authors, and others previously, have observed both decreased urinary excretion of coproporphyrin III and increased excretion of coproporphyrin I in the Dubin-Johnson syndrome, yielding an abnormally high ratio of I-isomer excretion. The “obligate heterozygotes” do not conform to this pattern in that decreased III-isomer excretion is not associated with increased I-isomer excretion to yield only a 7 per cent increase in percentage of coproporphyrin I excretion vs. controls. Although the authors.",
author = "Strand, {L. James} and Wolkoff, {Allan W.} and Arias, {Irwin M.}",
year = "1973",
month = "4",
day = "12",
doi = "10.1056/NEJM197304122881518",
language = "English (US)",
volume = "288",
pages = "795--796",
journal = "New England Journal of Medicine",
issn = "0028-4793",
publisher = "Massachussetts Medical Society",
number = "15",

}

TY - JOUR

T1 - Porphyrins in Dubin-Johnson Syndrome

AU - Strand, L. James

AU - Wolkoff, Allan W.

AU - Arias, Irwin M.

PY - 1973/4/12

Y1 - 1973/4/12

N2 - To the Editor: I have some questions and comments about the article by Wolkoff et al. entitled “Inheritance of the Dubin-Johnson Syndrome” (N Engl J Med 288:113, 1973). The authors, and others previously, have observed both decreased urinary excretion of coproporphyrin III and increased excretion of coproporphyrin I in the Dubin-Johnson syndrome, yielding an abnormally high ratio of I-isomer excretion. The “obligate heterozygotes” do not conform to this pattern in that decreased III-isomer excretion is not associated with increased I-isomer excretion to yield only a 7 per cent increase in percentage of coproporphyrin I excretion vs. controls. Although the authors.

AB - To the Editor: I have some questions and comments about the article by Wolkoff et al. entitled “Inheritance of the Dubin-Johnson Syndrome” (N Engl J Med 288:113, 1973). The authors, and others previously, have observed both decreased urinary excretion of coproporphyrin III and increased excretion of coproporphyrin I in the Dubin-Johnson syndrome, yielding an abnormally high ratio of I-isomer excretion. The “obligate heterozygotes” do not conform to this pattern in that decreased III-isomer excretion is not associated with increased I-isomer excretion to yield only a 7 per cent increase in percentage of coproporphyrin I excretion vs. controls. Although the authors.

UR - http://www.scopus.com/inward/record.url?scp=0015921482&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015921482&partnerID=8YFLogxK

U2 - 10.1056/NEJM197304122881518

DO - 10.1056/NEJM197304122881518

M3 - Letter

C2 - 4688724

AN - SCOPUS:0015921482

VL - 288

SP - 795

EP - 796

JO - New England Journal of Medicine

JF - New England Journal of Medicine

SN - 0028-4793

IS - 15

ER -