Population-based study of measles and measles immunization in human immunodeficiency virus-infected children

Paul Palumbo, Laura Hoyt, Kafui Demasio, James Oleske, Edward Connor

Research output: Contribution to journalArticle

92 Scopus citations

Abstract

This study reports the course of measles and results of measles immunization in a cohort of human immunodeficiency virus-infected children. Six cases of measles were identified. All had typical clinical manifestations, 5 of 6 developed pneumonia and 3 of 6 died. A measles intervention program consisting of serologicscreening and active immunization (measles-mumps-rubella (MMR)) was instituted in 1990. Among 127 children with data available for analysis (mean age, 6.7 years), only 35% had documentation of prior immunization with MMR. Among 80 children who had preimmunization measles serology reported, 56% were measles antibody-negative and 40% were antibody-positive; following intervention 36% remained measles antibody-negative. Six children lost measles antibody over time. MMR nonresponders had lower CD4 lymphocyte counts (303 ± 394) compared with responders (865 ± 677; P = 0.0058). Measles is a potentially fatal illness in human immunodeficiency virus-infected children. Prevention strategies are limited by low rates of age-appropriate MMR immunization, poor antibody responses to MMR inolder human immunodeficiency virus-infected children and seroreversion.

Original languageEnglish (US)
Pages (from-to)1008-1014
Number of pages7
JournalPediatric Infectious Disease Journal
Volume11
Issue number12
DOIs
StatePublished - Dec 1992
Externally publishedYes

Keywords

  • Acquired immunodeficiency syndrome
  • Human immunodeficiency virus
  • Measles

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

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