Abstract
This study reports the course of measles and results of measles immunization in a cohort of human immunodeficiency virus-infected children. Six cases of measles were identified. All had typical clinical manifestations, 5 of 6 developed pneumonia and 3 of 6 died. A measles intervention program consisting of serologicscreening and active immunization (measles-mumps-rubella (MMR)) was instituted in 1990. Among 127 children with data available for analysis (mean age, 6.7 years), only 35% had documentation of prior immunization with MMR. Among 80 children who had preimmunization measles serology reported, 56% were measles antibody-negative and 40% were antibody-positive; following intervention 36% remained measles antibody-negative. Six children lost measles antibody over time. MMR nonresponders had lower CD4 lymphocyte counts (303 ± 394) compared with responders (865 ± 677; P = 0.0058). Measles is a potentially fatal illness in human immunodeficiency virus-infected children. Prevention strategies are limited by low rates of age-appropriate MMR immunization, poor antibody responses to MMR inolder human immunodeficiency virus-infected children and seroreversion.
Original language | English (US) |
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Pages (from-to) | 1008-1014 |
Number of pages | 7 |
Journal | Pediatric Infectious Disease Journal |
Volume | 11 |
Issue number | 12 |
DOIs | |
State | Published - Dec 1992 |
Externally published | Yes |
Keywords
- Acquired immunodeficiency syndrome
- Human immunodeficiency virus
- Measles
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Microbiology (medical)
- Infectious Diseases